Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam - Wikidata - awgldk - TriplyDB

Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam

Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam

http://www.wikidata.org/entity/Q35748075

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Interface between tauopathies and synucleinopathies: A tale of two proteins Neuropathology of non-Alzheimer degenerative disorders The Synaptic Function of α-Synuclein Alpha-synuclein and tau: teammates in neurodegeneration?Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation.A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition.Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease Return of the cycad hypothesis - does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy.Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons.Lewy bodies.Tauopathic changes in the striatum of A53T α-synuclein mutant mouse model of Parkinson's disease.Proteomic identification of proteins in the human brain: Towards a more comprehensive understanding of neurodegenerative disease Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies.Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.Quantitative proteomics identifies surfactant-resistant alpha-synuclein in cerebral cortex of Parkinsonism-dementia complex of Guam but not Alzheimer's disease or progressive supranuclear palsy.Abnormal Paraplegin Expression in Swollen Neurites, τ- and α-Synuclein Pathology in a Case of Hereditary Spastic Paraplegia SPG7 with an Ala510Val Mutation Proteomics of human neurodegenerative diseases Neuropathology underlying clinical variability in patients with synucleinopathies.Confluence of α-synuclein, tau, and β-amyloid pathologies in dementia with Lewy bodies.The neurotoxin, MPP+, induces hyperphosphorylation of Tau, in the presence of alpha-Synuclein, in SH-SY5Y neuroblastoma cells.Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration New α- and γ-synuclein immunopathological lesions in human brain.Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia.The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodies.MultiTEP platform-based DNA vaccines for alpha-synucleinopathies: preclinical evaluation of immunogenicity and therapeutic potency.The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Amyloid fibril formation of alpha-synuclein is accelerated by preformed amyloid seeds of other proteins: implications for the mechanism of transmissible conformational diseases.Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series.Absence of alpha-synuclein pathology in postencephalitic parkinsonism.Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.Accumulation of phosphorylated alpha-synuclein in aging human brain.Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration.Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex.Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases.Dysfunction of Protein Quality Control in Parkinsonism-Dementia Complex of Guam.

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Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam

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The American Journal of Pathology

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Tau and alpha-synuclein pathol ...... entia complex patients of Guam

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Daniel P Perl

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M Luise Schmidt

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Mark S Forman

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Sanjay Kasturi

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Virginia M-Y Lee

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P2860

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

Parkinsonism-dementia complex on Guam - overview of clinical aspects.

Neuropathology of parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam: an update.

alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies.

beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.

Neuropathology of synuclein aggregates.

Lewy bodies in Alzheimer's disease: a neuropathological review of 145 cases using alpha-synuclein immunohistochemistry.

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Parkinson's disease

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1850878

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