Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. - Wikidata - awgldk - TriplyDB

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.

http://www.wikidata.org/entity/Q35791524

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Transiently transfected purine biosynthetic enzymes form stress bodies Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model Dynamic structural flexibility of α-synuclein Neuropathology in mice expressing mouse alpha-synuclein Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1 α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies.Gamma-synucleinopathy: neurodegeneration associated with overexpression of the mouse protein.Protein misfolding specifies recruitment to cytoplasmic inclusion bodies Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.DJ-1 deficient mice demonstrate similar vulnerability to pathogenic Ala53Thr human alpha-syn toxicity.Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice.Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers.Recent advances in our understanding of neurodegeneration.Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice.Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration.Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice.Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells The North American Multiple System Atrophy Study Group.Pallidal neuronal apolipoprotein E in pantothenate kinase-associated neurodegeneration recapitulates ischemic injury to the globus pallidus.Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model.A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity.Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways.Nurr1 in Parkinson's disease and related disorders.Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology.Aggregates assembled from overexpression of wild-type alpha-synuclein are not toxic to human neuronal cells Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.The Synucleinopathies: Twenty Years On.Protein aggregation in Parkinson's disease.Chemistry and biology of the ubiquitin signal.New insight into neurodegeneration: the role of proteomics.Is Parkinson's disease truly a prion-like disorder? An appraisal of current evidence.An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology.

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P2860

Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies.

http://www.wikidata.org/entity/Q35791524

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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name

Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.

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Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.

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Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.

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Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.

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Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.

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P1433

The American Journal of Pathology

P1476

Ubiquitination of alpha-synucl ...... ns in alpha-synucleinopathies.

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P2093

Aaron C Pawlyk

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Benoit I Giasson

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Deepak M Sampathu

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Virginia M-Y Lee

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P2860

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Recognition of the polyubiquitin proteolytic signal

Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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91-100

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scholarly article

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10.1016/S0002-9440(10)63633-4

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John Q. Trojanowski

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12819014

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P921

protein ubiquitination

P932

1868149

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