Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension
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Reciprocal Control of the Circadian Clock and Cellular Redox State - a Critical AppraisalCa(2+) signaling in the myocardium by (redox) regulation of PKA/CaMKIIRedox regulation of cGMP-dependent protein kinase Iα in the cardiovascular systemNitric oxide synthases in heart failureAbnormal Ca(2+) cycling in failing ventricular myocytes: role of NOS1-mediated nitroso-redox balanceThe vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressureBiochemical methods for monitoring protein thiol redox states in biological systemsOxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury.Oxidative stress in atrial fibrillation: an emerging role of NADPH oxidase.Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse.Prevention of PKG1α oxidation augments cardioprotection in the stressed heart.Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.Endothelium-Derived Hyperpolarization and Coronary Vasodilation: Diverse and Integrated Roles of Epoxyeicosatrienoic Acids, Hydrogen Peroxide, and Gap Junctions.Pathophysiology of hypertension in the absence of nitric oxide/cyclic GMP signaling.Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system.Structures of cGMP-Dependent Protein Kinase (PKG) Iα Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability.Diverse Functions of Endothelial NO Synthases System: NO and EDH.Protein kinase G oxidation is a major cause of injury during sepsis.Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G.Roles for cytosolic NADPH redox in regulating pulmonary artery relaxation by thiol oxidation-elicited subunit dimerization of protein kinase G1αDisulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels.A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.cGMP becomes a drug target.Vasodilatory mechanisms of beta receptor blockade.Contribution of oxidative stress to endothelial dysfunction in hypertensionMeeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research.cGMP: transition from bench to bedside: a report of the 6th International Conference on cGMP Generators, Effectors and Therapeutic Implications.Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart.Endothelial dysfunction and vascular disease - a 30th anniversary update.The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43.Heme Oxygenases in Cardiovascular Health and Disease.Oxidative Stress and Hypertensive Diseases.Responses to reductive stress in the cardiovascular system.Reactive oxygen species: key regulators in vascular health and diseases.Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse.Role of the renal sympathetic nerve in renal glucose metabolism during the development of type 2 diabetes in rats.Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity.Proof of Principle for a Novel Class of Antihypertensives That Target the Oxidative Activation of PKG Iα (Protein Kinase G Iα).
P2860
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P2860
Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Single atom substitution in mo ...... sensing to cause hypertension
@ast
Single atom substitution in mo ...... sensing to cause hypertension
@en
type
label
Single atom substitution in mo ...... sensing to cause hypertension
@ast
Single atom substitution in mo ...... sensing to cause hypertension
@en
prefLabel
Single atom substitution in mo ...... sensing to cause hypertension
@ast
Single atom substitution in mo ...... sensing to cause hypertension
@en
P2860
P356
P1433
P1476
Single atom substitution in mo ...... sensing to cause hypertension
@en
P2093
Oleksandra Prysyazhna
P2860
P2888
P304
P356
10.1038/NM.2603
P407
P577
2012-01-15T00:00:00Z