Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. - Wikidata - awgldk - TriplyDB

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

http://www.wikidata.org/entity/Q35750233

about

A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease Synaptic Cell Adhesion Molecules in Alzheimer's Disease Alzheimer's Disease: Mechanism and Approach to Cell Therapy Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease Hijacking PrP(c)-dependent signal transduction: when prions impair Aβ clearance Interaction between prion protein and Aβ amyloid fibrils revisited The dendritic hypothesis for Alzheimer's disease pathophysiology.Functions of the cellular prion protein, the end of Moore's law, and Ockham's razor theory Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1 The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative Diseases Amyloid β Protein and Alzheimer's Disease: When Computer Simulations Complement Experimental Studies.Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents Plasma prion protein concentration and progression of Alzheimer disease.Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).High resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C))Iron is a specific cofactor for distinct oxidation- and aggregation-dependent Aβ toxicity mechanisms in a Drosophila model.Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicity Unique Properties of the Rabbit Prion Protein Oligomer Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo Cellular prion protein and Alzheimer disease: link to oligomeric amyloid-β and neuronal cell death Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease Soluble prion protein and its N-terminal fragment prevent impairment of synaptic plasticity by Aβ oligomers: Implications for novel therapeutic strategy in Alzheimer's disease.The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers.Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease.Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Aβ42 induced cytotoxicity CSF prion protein concentration and cognition in patients with Alzheimer disease Mutational analysis of PRNP in Alzheimer's disease and frontotemporal dementia in China.Fyn kinase inhibition as a novel therapy for Alzheimer's disease.Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer's Disease.Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.Prion protein oligomer and its neurotoxicity.Prion disease: a tale of folds and strains.Overcoming barriers and thresholds - signaling of oligomeric Aβ through the prion protein to Fyn.Biophysical studies of the amyloid β-peptide: interactions with metal ions and small molecules.Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.

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P2860

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

http://www.wikidata.org/entity/Q35750233

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

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Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

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type

label

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

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Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

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prefLabel

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

@ast

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

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P1433

Human Molecular Genetics

P1476

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death.

@en

P2093

Hyoung-gon Lee

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Hyun-Pil Lee

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Robert B Petersen

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Wataru Kudo

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Wen-Quan Zou

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P2860

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

Memory impairment in transgenic Alzheimer mice requires cellular prion protein.

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

Prion protein and Abeta-related synaptic toxicity impairment.

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1138-1144

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scholarly article

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10.1093/HMG/DDR542

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5

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21

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Mark Anthony Smith

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2011-11-18T00:00:00Z

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51815005

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22100763

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P921

Prion protein family

P932

3277312

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