Construction of hybrid peptide synthetases by module and domain fusions.
about
Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilisPhylogenetic analysis of condensation domains in NRPS sheds light on their functional evolutionOn the structural and functional modularity of glycinamide ribonucleotide formyltransferases.Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes.Recurrent adenylation domain replacement in the microcystin synthetase gene cluster.The minimized dead-end elimination criterion and its application to protein redesign in a hybrid scoring and search algorithm for computing partition functions over molecular ensembles.Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugsDirected evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides.The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains.Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases.Nonribosomal peptide synthase gene clusters for lipopeptide biosynthesis in Bacillus subtilis 916 and their phenotypic functionsIn vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coliUnraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites.Unusual Biosynthesis and Structure of Locillomycins from Bacillus subtilis 916A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.Preparation of Semisynthetic Peptides Macrocycles Using Split Inteins.Nonribosomal Peptide Synthesis-Principles and Prospects.Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptidesExplorations of catalytic domains in non-ribosomal peptide synthetase enzymologyA free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis.Biocombinatorial Synthesis of Novel Lipopeptides by COM Domain-Mediated Reprogramming of the Plipastatin NRPS Complex.Translocation of the thioesterase domain for the redesign of plipastatin synthetase.The structural role of the carrier protein--active controller or passive carrier.Genetic manipulation of non-ribosomal peptide synthetases to generate novel bioactive peptide products.Optimizing dimodular nonribosomal peptide synthetases and natural dipeptides in an Escherichia coli heterologous host.Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine.Importance of 3-hydroxy fatty acid composition of lipopeptides for biosurfactant activityTargeted Gene Disruption of the Cyclo (L-Phe, L-Pro) Biosynthetic Pathway in Streptomyces sp. US24 Strain.Biosynthesis of novel Pyoverdines by domain substitution in a nonribosomal peptide synthetase of Pseudomonas aeruginosa.Construction of hybrid peptide synthetases for the production of alpha-l-aspartyl-l-phenylalanine, a precursor for the high-intensity sweetener aspartame.Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF.Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering.Nonribosomal Peptides from Marine Microbes and Their Antimicrobial and Anticancer Potential.Structures of carboxylic acid reductase reveal domain dynamics underlying catalysis.Engineered biosynthesis of the peptide antibiotic bacitracin in the surrogate host Bacillus subtilis.Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange.Reprogramming the Biosynthesis of Cyclodepsipeptide Synthetases to Obtain New Enniatins and Beauvericins.
P2860
Q24561994-5E13F156-7E2A-480F-83D2-8FE2B565B4DCQ28211282-68D144C0-2CDA-4928-8A18-2CB7929C9A7BQ28757531-393D88E1-4EF8-4824-9D16-A0DB860583A1Q33193083-F7E08746-E673-4C91-9E14-9F9AA52411CEQ33290356-4CD86AE9-464B-4292-97E6-04DD11412DFEQ33301052-61887D54-48A8-4C1C-8D4F-18CB3FF5E499Q33320836-009B8E32-3D93-4B6E-8EBC-ACB2F9F5ECF0Q33801128-8C79123E-CB86-4CC4-AE49-4EC6494D17F0Q33910739-DE03C0A4-2504-4EDC-8E12-1EB5EE53CA90Q34249735-F0BCA0BE-BA43-443B-99A0-184990FE4852Q34283045-0443E9DE-4234-4F48-B46A-0DF1B3BD4477Q34391937-E6A5CDB5-8FA9-47DF-86C4-2412378CC560Q34748009-A893BE22-0DCF-4C94-A5CF-DAF4791DA175Q34775615-A4CB29DE-84F0-4668-864E-1A762CEDDFBDQ35058923-24E73FC5-6DFF-45A2-9FB6-59B282FE2516Q36033311-2BFBF1C0-50D3-462F-8FCC-92E9697CCEC2Q36104021-4AC86A5F-680E-4573-A335-5A96A217E7F6Q36156165-57CFC34A-F17F-49F4-AD24-F97FD455D1B4Q36316177-D7937698-EF00-4D64-9074-EB12DE374FF7Q36416681-984F0501-996F-4EEA-AD01-3D8CCE8E0F4AQ36729066-66728235-454E-4C20-8820-61F080D5C86BQ37132922-4986D868-C19C-4A15-A2E9-CA71F4FA8217Q37418682-15BCAB8F-A125-4016-B31E-0D873BCEC108Q37529222-02C12418-2834-4C8E-A917-EF76C9A637C1Q38038812-EAE4F109-482B-4069-844B-B7EB945FE619Q38248553-328E9FCB-1065-4DFC-B8AE-11049EEA694EQ39383814-3B953BE3-59F6-4434-9A54-2D179E22B77FQ40103158-6319BA50-FA01-442A-841C-765A62EF6685Q40713564-6AEEE7AE-16E8-4876-812B-64FC5EE2BE01Q41973720-BF063F43-A485-4A65-BC63-02300F5794C3Q42118810-8077B05B-839C-448C-9754-817A5160BAA4Q44658356-1BA927D2-0737-4101-8DA0-6CCDFB2C0AD5Q46119916-C949648D-9056-4703-93A1-1FC785A0520DQ47325243-5D342F9D-CC9F-4194-A819-5BCEBB7D1CB3Q48018515-01C27F89-7F2D-4F9E-BCA1-A749FC3662C5Q48107712-7D5A7BF2-051A-465E-92A9-3BB76D64AA6DQ48354158-6D3497D5-C4F4-4F86-898A-03AFC77E7155Q50225993-95FFA49B-ED8A-487D-BBBE-93914B58BF56Q51608114-EBC17EEC-FCAA-48A2-96FD-FDFD0F9B8495
P2860
Construction of hybrid peptide synthetases by module and domain fusions.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Construction of hybrid peptide synthetases by module and domain fusions.
@ast
Construction of hybrid peptide synthetases by module and domain fusions.
@en
type
label
Construction of hybrid peptide synthetases by module and domain fusions.
@ast
Construction of hybrid peptide synthetases by module and domain fusions.
@en
prefLabel
Construction of hybrid peptide synthetases by module and domain fusions.
@ast
Construction of hybrid peptide synthetases by module and domain fusions.
@en
P2093
P2860
P356
P1476
Construction of hybrid peptide synthetases by module and domain fusions.
@en
P2093
D Schwarzer
M A Marahiel
P2860
P304
P356
10.1073/PNAS.100075897
P407
P577
2000-05-01T00:00:00Z