The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
about
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetlesThe 1.92-A structure of Streptomyces coelicolor A3(2) CYP154C1. A new monooxygenase that functionalizes macrolide ring systemsComparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathwaysThe crystal structure of a mammalian fatty acid synthaseAcyl-CoA hydrolysis by the high molecular weight protein 1 subunit of yersiniabactin synthetase: mutational evidence for a cascade of four acyl-enzyme intermediates during hydrolytic editingAntineoplastic agents from natural sources: achievements and future directions.Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes.In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.Automated genome mining for natural products.A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis.In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont.The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15.In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases.Assembly of aryl-capped siderophores by modular peptide synthetases and polyketide synthases.Manzamines: a potential for novel cures.Natural products: a continuing source of novel drug leadsThe Janthinobacterium sp. HH01 genome encodes a homologue of the V. cholerae CqsA and L. pneumophila LqsA autoinducer synthases.Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase.In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coliRecent developments in the production of novel polyketides by combinatorial biosynthesis.Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517.The enzymology of combinatorial biosynthesis.SEARCHPKS: A program for detection and analysis of polyketide synthase domains.Construction of hybrid peptide synthetases by module and domain fusions.Allopatric integrations selectively change host transcriptomes, leading to varied expression efficiencies of exotic genes in Myxococcus xanthus.Structural elements of an NRPS cyclization domain and its intermodule docking domain.Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.Isolation and characterisation of the epothilone gene cluster with flanks from high alkalotolerant strain Sorangium cellulosum (So0157-2).The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.ClusterMine360: a database of microbial PKS/NRPS biosynthesis.Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents.Diversity of epothilone producers among Sorangium strains in producer-positive soil habitats.Structure and function of eukaryotic fatty acid synthases.The structures of type I polyketide synthases.Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase.Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery.Iterative polyketide biosynthesis by modular polyketide synthases in bacteria.Natural compounds for pediatric cancer treatment.Recent advances in engineering nonribosomal peptide assembly lines.
P2860
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P2860
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
description
2000 nî lūn-bûn
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2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2000 թվականի փետրվարին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@ast
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@en
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@nl
type
label
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@ast
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@en
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@nl
prefLabel
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@ast
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@en
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@nl
P2093
P1476
The biosynthetic gene cluster ...... m Sorangium cellulosum So ce90
@en
P2093
A Stratmann
B Nowak-Thompson
M Milnamow
P304
P356
10.1016/S1074-5521(00)00075-2
P407
P577
2000-02-01T00:00:00Z