Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing. - Wikidata - awgldk - TriplyDB

Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.

Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.

http://www.wikidata.org/entity/Q35750959

about

The DGCR8 RNA-binding heme domain recognizes primary microRNAs by clamping the hairpin Processing of microRNA primary transcripts requires heme in mammalian cells Biology of Heme in Mammalian Erythroid Cells and Related Disorders Biogenesis and mechanism of action of small non-coding RNAs: insights from the point of view of structural biology Dimerization and Heme Binding Are Conserved in Amphibian and Starfish Homologues of the microRNA Processing Protein DGCR8 TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression.Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8.MicroRNAs: New players in cancer prevention targeting Nrf2, oxidative stress and inflammatory pathways.miRNA-mediated risk for schizophrenia in 22q11.2 deletion syndrome.Cobalt(III) Protoporphyrin Activates the DGCR8 Protein and Can Compensate microRNA Processing Deficiency.Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8.Influence of microRNA on the maintenance of human iron metabolism The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.Regulation of iron homeostasis by microRNAs.Heme sensor proteins.Human RNAi pathway: crosstalk with organelles and cells.MicroRNAs: the fine modulators of liver development and function.The role of vitamins and minerals in modulating the expression of microRNA.Heme and erythropoieis: more than a structural role.Regulatory Fe(II/III) heme: the reconstruction of a molecule's biography.Stress response factors as hub-regulators of microRNA biogenesis: implication to the diseased heart.Heme Gazing: Illuminating Eukaryotic Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors.CO and NO bind to Fe(II) DiGeorge critical region 8 heme but do not restore primary microRNA processing activity.Drosha and Dicer: Slicers cut from the same cloth.Heme promotes transcriptional and demethylase activities of Gis1, a member of the histone demethylase JMJD2/KDM4 family.Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs.Interaction between Mitochondrial Reactive Oxygen Species, Heme Oxygenase, and Nitric Oxide Synthase Stimulates Phagocytosis in Macrophages.Ultrafast dynamics of hemin aggregates.Microprocessor depends on hemin to recognize the apical loop of primary microRNA.Experimental Methods for Studying Cellular Heme Signaling.

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P2860

Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.

http://www.wikidata.org/entity/Q35750959

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Ferric, not ferrous, heme acti ...... r primary microRNA processing.

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Ferric, not ferrous, heme acti ...... r primary microRNA processing.

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type

label

Ferric, not ferrous, heme acti ...... r primary microRNA processing.

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Ferric, not ferrous, heme acti ...... r primary microRNA processing.

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prefLabel

Ferric, not ferrous, heme acti ...... r primary microRNA processing.

@ast

Ferric, not ferrous, heme acti ...... r primary microRNA processing.

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PNAS.1114514109

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Proceedings of the National Academy of Sciences of the United States of America

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Ferric, not ferrous, heme acti ...... or primary microRNA processing

@en

P2093

Aaron T Smith

http://www.w3.org/2001/XMLSchema#string

Feng Guo

http://www.w3.org/2001/XMLSchema#string

Judith N Burstyn

http://www.w3.org/2001/XMLSchema#string

Rachel Senturia

http://www.w3.org/2001/XMLSchema#string

Yanqiu Chen

http://www.w3.org/2001/XMLSchema#string

P2860

The nuclear RNase III Drosha initiates microRNA processing

The Microprocessor complex mediates the genesis of microRNAs

The Drosha-DGCR8 complex in primary microRNA processing

Crystal structure of human DGCR8 core

MicroRNAs: target recognition and regulatory functions

MicroRNA biogenesis: there's more than one way to skin a cat

Structure of the dimerization domain of DiGeorge Critical Region 8

The functions of animal microRNAs

Processing of primary microRNAs by the Microprocessor complex

Biogenesis of small RNAs in animals

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1919-1924

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scholarly article

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10.1073/PNAS.1114514109

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6

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109

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22308374

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