Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models
about
Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model ConstructionDrug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation.Evaluating pharmacokinetic and pharmacodynamic interactions with computational models in supporting cumulative risk assessment.Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development.Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modellingA clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABA(A) receptor modulator - an in vitro and in vivo comparison.Predicting drug-drug interactions: an FDA perspectiveUse of physiologically based pharmacokinetic modeling for assessment of drug-drug interactions.Predicting drug-drug interactions: application of physiologically based pharmacokinetic models under a systems biology approach.Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies.Physiologically based pharmacokinetic and pharmacodynamic modeling in cancer drug development: status, potential and gaps.Have physiologically-based pharmacokinetic models delivered?A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic Model.Long-term human primary hepatocyte cultures in a microfluidic liver biochip show maintenance of mRNA levels and higher drug metabolism compared with Petri cultures.Investigation of an alternative generic model for predicting pharmacokinetic changes during physiological stress.A semiphysiological population pharmacokinetic model for dynamic inhibition of liver and gut wall cytochrome P450 3A by voriconazole.Simulation of differential drug pharmacokinetics under heat and exercise stress using a physiologically based pharmacokinetic modeling approach.Bioavailability considerations in evaluating drug-drug interactions using the population pharmacokinetic approach.Use of Human Plasma Samples to Identify Circulating Drug Metabolites that Inhibit Cytochrome P450 Enzymes.Toxicology of Specific Substances
P2860
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P2860
Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Dynamically simulating the int ...... armacokinetic (WB-PBPK) models
@ast
Dynamically simulating the int ...... armacokinetic (WB-PBPK) models
@en
type
label
Dynamically simulating the int ...... armacokinetic (WB-PBPK) models
@ast
Dynamically simulating the int ...... armacokinetic (WB-PBPK) models
@en
prefLabel
Dynamically simulating the int ...... armacokinetic (WB-PBPK) models
@ast
Dynamically simulating the int ...... armacokinetic (WB-PBPK) models
@en
P2093
P2860
P356
P1476
Dynamically simulating the int ...... armacokinetic (WB-PBPK) models
@en
P2093
Andrea N Edginton
Christoph Niederalt
In-Jin Jang
Michael Sevestre
Michaela Vossen
Stefan Willmann
P2860
P2888
P356
10.1186/1742-4682-4-13
P577
2007-03-26T00:00:00Z
P5875
P6179
1002107294