From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools.
about
Predicting plasma concentrations of bisphenol A in children younger than 2 years of age after typical feeding schedules, using a physiologically based toxicokinetic modelThe use of modeling tools to drive efficient oral product designSpatio-temporal simulation of first pass drug perfusion in the liverA mechanistic, model-based approach to safety assessment in clinical developmentBayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant PopulationsBuilding a 3D Virtual Liver: Methods for Simulating Blood Flow and Hepatic Clearance on 3D StructuresDevelopment of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly IndividualsFocus on success: using a probabilistic approach to achieve an optimal balance of compound properties in drug discovery.Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development.Network pharmacodynamic models for customized cancer therapy.Prediction of a potentially effective dose in humans for BAY 60-5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modellingDynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) modelsA Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.Predictive models for oral drug absorption: from in silico methods to integrated dynamical models.On the anticipation of the human dose in first-in-man trials from preclinical and prior clinical information in early drug development.Physiologically based approaches towards the prediction of pharmacokinetics: in vitro-in vivo extrapolation.Development of a paediatric population-based model of the pharmacokinetics of rivaroxaban.The in silico child: using simulation to guide pediatric drug development and manage pediatric pharmacotherapy.Physiologically based pharmacokinetics (PBPK).Experimental models for predicting drug absorption and metabolism.Pros and cons of methods used for the prediction of oral drug absorption.Modeling bioavailability to organs protected by biological barriers.Development of Physiologically Based Organ Models to Evaluate the Pharmacokinetics of Drugs in the Testes and the Thyroid Gland.Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.Evaluation and optimisation of current milrinone prescribing for the treatment and prevention of low cardiac output syndrome in paediatric patients after open heart surgery using a physiology-based pharmacokinetic drug-disease model.Whole-body physiologically based pharmacokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption.Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children.A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.The feasibility of physiologically based pharmacokinetic modeling in forensic medicine illustrated by the example of morphine.A physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model of the histone deacetylase (HDAC) inhibitor vorinostat for pediatric and adult patients and its application for dose specification.Development and validation of a physiology-based model for the prediction of pharmacokinetics/toxicokinetics in rabbits.In silico approach in reveal traditional medicine plants pharmacological material basis.
P2860
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P2860
From physicochemistry to absorption and distribution: predictive mechanistic modelling and computational tools.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
From physicochemistry to absor ...... lling and computational tools.
@ast
From physicochemistry to absor ...... lling and computational tools.
@en
From physicochemistry to absor ...... lling and computational tools.
@nl
type
label
From physicochemistry to absor ...... lling and computational tools.
@ast
From physicochemistry to absor ...... lling and computational tools.
@en
From physicochemistry to absor ...... lling and computational tools.
@nl
prefLabel
From physicochemistry to absor ...... lling and computational tools.
@ast
From physicochemistry to absor ...... lling and computational tools.
@en
From physicochemistry to absor ...... lling and computational tools.
@nl
P2860
P356
P1476
From physicochemistry to absor ...... lling and computational tools.
@en
P2093
Jörg Lippert
Stefan Willmann
P2860
P304
P356
10.1517/17425255.1.1.159
P407
P577
2005-06-01T00:00:00Z