Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. - Wikidata - awgldk - TriplyDB

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease.

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease.

http://www.wikidata.org/entity/Q35763138

about

Role of exosomes/microvesicles in the nervous system and use in emerging therapies Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?Microvesicles: novel biomarkers for neurological disorders Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes Is tau ready for admission to the prion club?Exosomal miRNAs as cancer biomarkers and therapeutic targets Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools Extracellular Vesicles and a Novel Form of Communication in the Brain Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles Myeloid Extracellular Vesicles: Messengers from the Demented Brain Antibody-Based Assays for Phenotyping of Extracellular Vesicles Exosomes as Novel Regulators of Adult Neurogenic Niches miRNAs: biological and clinical determinants in epilepsy Molecular diagnostics of neurodegenerative disorders Exosomes function in cell-cell communication during brain circuit development Exosomes as mediators of neuroinflammation Exosomes: an overview of biogenesis, composition and role in ovarian cancer Mechanisms of protein seeding in neurodegenerative diseases Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem The role of tau in neurodegenerative diseases and its potential as a therapeutic target Proteolytic clearance of extracellular α-synuclein as a new therapeutic approach against Parkinson disease MicroRNAs as biomarkers for CNS disease Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.Depletion of microglia and inhibition of exosome synthesis halt tau propagation.Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease Extracellular vesicle-mediated transfer of genetic information between the hematopoietic system and the brain in response to inflammation Impact of lysosome status on extracellular vesicle content and release Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling Spreading of pathology in neurodegenerative diseases: a focus on human studies Legal but lethal: functional protein aggregation at the verge of toxicity Exosomes and Their Role in the Life Cycle and Pathogenesis of RNA Viruses ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma The release and trans-synaptic transmission of Tau via exosomes Trans-synaptic spread of tau pathology in vivo Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations.

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Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease.

http://www.wikidata.org/entity/Q35763138

description

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name

Exosome-associated tau is secr ...... id in early Alzheimer disease.

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Exosome-associated tau is secr ...... id in early Alzheimer disease.

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type

label

Exosome-associated tau is secr ...... id in early Alzheimer disease.

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Exosome-associated tau is secr ...... id in early Alzheimer disease.

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Exosome-associated tau is secr ...... id in early Alzheimer disease.

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Exosome-associated tau is secr ...... id in early Alzheimer disease.

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Journal of Biological Chemistry

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Exosome-associated tau is secr ...... id in early Alzheimer disease.

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P2093

Ann C McKee

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Bruce Jackson

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Garth F Hall

http://www.w3.org/2001/XMLSchema#string

Mario Raya

http://www.w3.org/2001/XMLSchema#string

Norman C Y Lee

http://www.w3.org/2001/XMLSchema#string

Sarmad Saman

http://www.w3.org/2001/XMLSchema#string

Sudad Saman

http://www.w3.org/2001/XMLSchema#string

Suhad Miro

http://www.w3.org/2001/XMLSchema#string

Victor E Alvarez

http://www.w3.org/2001/XMLSchema#string

WonHee Kim

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P2860

Tau interacts with src-family non-receptor tyrosine kinases

A protein factor essential for microtubule assembly

Transmission and spreading of tauopathy in transgenic mouse brain

Neuropathological stageing of Alzheimer-related changes

Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease

ExoCarta: A compendium of exosomal proteins and RNA

Targeting oligomers in neurodegenerative disorders: lessons from α-synuclein, tau, and amyloid-β peptide

Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy

Microtubule-dependent oligomerization of tau. Implications for physiological tau function and tauopathies

Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes.

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3842-3849

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6

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287

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51773734

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22057275

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Alzheimer's disease

phosphorylation

cerebrospinal fluid

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3281682

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