Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. - Wikidata - awgldk - TriplyDB

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.

http://www.wikidata.org/entity/Q35763361

about

The PICALM protein plays a key role in iron homeostasis and cell proliferation The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase Clathrin adaptor CALM/PICALM is associated with neurofibrillary tangles and is cleaved in Alzheimer's brains Genes associated with Alzheimer's disease: an overview and current status Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1 Late-Onset Alzheimer's Disease Genes and the Potentially Implicated Pathways Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Oxidative stress in Alzheimer's and Parkinson's diseases: insights from the yeast Saccharomyces cerevisiae Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes REST and stress resistance in ageing and Alzheimer's disease Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis Efforts to make and apply humanized yeast Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease Effects of CD2-associated protein deficiency on amyloid-β in neuroblastoma cells and in an APP transgenic mouse model.Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance Analysis of ER resident proteins in Saccharomyces cerevisiae: implementation of H/KDEL retrieval sequences.Enteroviruses harness the cellular endocytic machinery to remodel the host cell cholesterol landscape for effective viral replication.Screening assay for small-molecule inhibitors of synaptojanin 1, a synaptic phosphoinositide phosphatase.Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.ATP5H/KCTD2 locus is associated with Alzheimer's disease risk.Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease.Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease.ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.Genetic architectures of psychiatric disorders: the emerging picture and its implications.Genome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-β42: importance of lipid homeostasis.Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576)Identification of common genetic modifiers of neurodegenerative diseases from an integrative analysis of diverse genetic screens in model organisms The Biochemical Properties and Functions of CALM and AP180 in Clathrin Mediated Endocytosis.Curcumin prevents formation of polyglutamine aggregates by inhibiting Vps36, a component of the ESCRT-II complex.Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics.Alzheimer's disease risk genes and mechanisms of disease pathogenesis Approaching the functional annotation of fungal virulence factors using cross-species genetic interaction profiling.Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.

P2860

Q24298166-E6F8D523-0359-4464-A0EE-C55D2AC055C5 Q24298394-9AD52EB7-CFC7-4BF2-B319-32A67B163C85 Q24338376-111CA50B-A472-4594-8EA7-BDD0F279B989 Q24338543-F1DE6E52-6547-4769-B74F-CF8C18EF498D Q26747803-12186F38-FA1B-4A9F-A006-9CE68E1E3D62 Q26776093-16EE5582-7EBE-4C67-A3E3-B01FC111B2EE Q26799208-92E3E053-6EA4-4D02-9B4A-6015CFF308D1 Q26800063-6634E7CF-4C08-43C1-825A-7F19118C8493 Q27014964-EE781888-A61F-4728-998C-A15C6D6E1858 Q27026907-CA840E5F-38C5-4E2B-8C27-5E21744C0671 Q27692067-27B7EEB3-031F-45CB-9E4C-5761056AD1F1 Q28118988-B1356CA0-F6DF-42FF-B277-E3FF3DD69DE0 Q28236857-4B47AD36-61F7-484C-B209-EA10F84D9D77 Q28551966-031BECAA-7211-4ADD-88F8-42CBCE18FB33 Q28587217-9F0496A3-5ACF-46EE-B7C1-466248D0E781 Q28602193-AF9E5DEE-26BF-4105-9FD9-9B09EECF0E10 Q29048183-2A0AD622-9D3B-4B6F-AE37-C407671CD9DD Q30009187-484A836D-A4A0-4E6D-8051-EED94A3A3924 Q30009897-B37E7786-BFB0-4B48-9933-9A6337D8370C Q30090186-BBD7B03F-A70F-4E37-87C0-1548C0310D64 Q30537408-EB8B7CE0-C766-4A4B-A4BF-74B560A49607 Q30552405-D6AA11EE-191C-411C-A08E-73BE978687FE Q33561690-45E44410-78B8-48BA-B7EB-A028EB08567E Q33616462-EFA5C5F2-1E0C-4090-9BCF-8DAA6D595521 Q33652534-A35BA704-7A18-42A2-B538-AC46245BDAF9 Q33745617-33F4851F-5526-44C5-8443-C7BB1ED8A2AF Q33745920-4A97C62D-C6E1-464A-8978-7F8CFE7C4E4F Q33803215-877D42FF-7816-4609-A1D6-A5501ABD9BB4 Q33913554-C52CD00E-18BB-40BF-AC3C-FCE4709FA664 Q33949729-83D7A25F-C181-4F21-8D65-BDF032B62306 Q33975871-3F55BA8B-7583-4CFD-96BD-3C7D234BFC56 Q34095829-31DC2B58-B183-4961-A2E7-31BB5FBDE0AC Q34158629-A45E5C21-E34B-4F0E-A279-A42516FC027A Q34324323-9AC1DC98-EF7D-41A1-A79E-1B12C9767D18 Q34374859-FC4FDC64-3589-4C83-9C47-FE1B4E14FD4D Q34380191-DC39C0B0-2936-45AA-BF6B-E2ED09CF2546 Q34424308-4DFB4026-8CD5-49E6-85A8-979B77D7676D Q34425904-E2724955-4755-4DEF-BBA8-744AE320F9F3 Q34539851-EEA8D124-FFEA-4E3B-87E5-B230B81BD50A Q34550197-FC660289-2377-40D1-8F39-C0321E3576C5

P2860

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.

http://www.wikidata.org/entity/Q35763361

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

2011年论文

@zh

2011年论文

@zh-cn

name

Functional links between Aβ to ...... disease risk factors in yeast.

@ast

Functional links between Aβ to ...... disease risk factors in yeast.

@en

type

label

Functional links between Aβ to ...... disease risk factors in yeast.

@ast

Functional links between Aβ to ...... disease risk factors in yeast.

@en

prefLabel

Functional links between Aβ to ...... disease risk factors in yeast.

@ast

Functional links between Aβ to ...... disease risk factors in yeast.

@en

P1433

Q35763361-BB7A3699-7AC0-4EFB-A3B4-10B8FBE9FBF0

P1476

Q35763361-82121ECF-B442-4458-9D10-869B9D383D56

P2093

Q35763361-00EFA12D-1DEC-42A1-A46C-518CC58BD593

Q35763361-067E778B-DEC1-4FCC-8E51-259F1083297B

Q35763361-6166B8DE-1A6B-42E5-AF51-F6FBE9FD1F27

Q35763361-6EC4AC38-C11A-4961-B88A-E26EBBD07128

Q35763361-72052347-4209-4A4A-A8DC-86B0C1BD9204

Q35763361-72591C4F-B9C1-4E13-A2F4-1332A8E1C50D

Q35763361-74712CD4-83A2-4CD2-99C5-E76CCB6338A7

Q35763361-788053F9-4399-4FB8-9C0F-C6055E3FBD74

Q35763361-96185D20-CFBE-4A51-AA5E-13020EAB6F01

Q35763361-B6FF24C4-0A1E-4E1C-A219-ACF214028284

P2860

Q35763361-032BD345-18E0-4119-8CE0-A2C7979EE637

Q35763361-08BE89FF-8AC1-4234-8A76-18E313508223

Q35763361-09654734-6B77-49F5-868F-478926EC1EFF

Q35763361-0C908784-EBF2-4191-902D-F60F9008D5EB

Q35763361-0E7D28B1-4961-4EE9-B358-A7F1F0499EB1

Q35763361-0ECF5F75-848B-40D3-BB45-2EB40A1AB7E9

Q35763361-103BCD92-F2C2-43F5-A447-ED56600E17A1

Q35763361-136295A2-2BE6-4FD8-82A7-87F4EDF552F5

Q35763361-1608F375-E3A3-4ACB-B32E-4A02ABB0CA47

Q35763361-1878BF91-F23C-4612-AB7F-2D45D180E9E3

P304

Q35763361-BE257083-8A45-47EA-9C0B-86AA6D8CCE07

P31

Q35763361-942E0150-5701-42B1-8DB6-64B16DF61045

P356

Q35763361-73B60CD2-B420-41B1-BD48-38D763C49F26

P407

Q35763361-506227BD-DA70-4498-926A-34C37F77EF48

P433

Q35763361-4EB29CEF-BA8D-4CC6-9002-4AA6BF146B12

P478

Q35763361-852CE6B5-13C8-4D91-AACB-922573D7D61D

P50

Q35763361-629C7570-6AAA-4C3C-B4BB-34E51A46DDFE

Q35763361-6F2EC52B-7D65-4690-9917-B2DFEEFFC626

Q35763361-BCE6593C-C049-43BB-858E-BBF68E41234B

Q35763361-CD5039DC-495D-4CD7-A93E-350A61683B89

P577

Q35763361-4B8C1697-311B-4C32-8D33-131EFCC51F57

P5875

Q35763361-17AF350D-7C9A-4ABB-9D72-230E7B04EB95

P698

Q35763361-E0F3CAEE-DB7C-4DF5-AEB1-E3F6DAF95F2E

P921

Q35763361-ABF6E480-06E7-49E2-972F-6272F1BD4097

P932

Q35763361-7C94A73C-B3C4-4FED-8CE9-E9DBC5376D89

P356

SCIENCE.1213210

P1433

P1476

Functional links between Aβ to ...... disease risk factors in yeast.

@en

P2093

Anders Olofsson

http://www.w3.org/2001/XMLSchema#string

Antonio Parrado

http://www.w3.org/2001/XMLSchema#string

Brooke J Bevis

http://www.w3.org/2001/XMLSchema#string

Chee Yeun Chung

http://www.w3.org/2001/XMLSchema#string

Denis A Evans

http://www.w3.org/2001/XMLSchema#string

Guy A Caldwell

http://www.w3.org/2001/XMLSchema#string

Haesun Han

http://www.w3.org/2001/XMLSchema#string

Jessica L Goodman

http://www.w3.org/2001/XMLSchema#string

Joshua M Shulman

http://www.w3.org/2001/XMLSchema#string

Julie S Valastyan

http://www.w3.org/2001/XMLSchema#string

P2860

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

A second generation human haplotype map of over 3.1 million SNPs

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

PtdIns(4,5)P2 turnover is required for multiple stages during clathrin- and actin-dependent endocytic internalization

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167.

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

Identification and characterization of a nerve terminal-enriched amphiphysin isoform

P304

1241-1245

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCIENCE.1213210

http://www.w3.org/2001/XMLSchema#string

P407

P433

6060

http://www.w3.org/2001/XMLSchema#string

P478

334

http://www.w3.org/2001/XMLSchema#string

P50

Rudolph E. Tanzi

Susan Lindquist

David A Bennett

P577

2011-10-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51751212

http://www.w3.org/2001/XMLSchema#string

P698

22033521

http://www.w3.org/2001/XMLSchema#string

P921

Alzheimer's disease

P932

3281757

http://www.w3.org/2001/XMLSchema#string