The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses. - Wikidata - awgldk - TriplyDB

The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses.

The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses.

http://www.wikidata.org/entity/Q35763894

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Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date Deciphering the link between PI3K and PAK: An opportunity to target key pathways in pancreatic cancer?Predicting mTOR inhibitors with a classifier using recursive partitioning and Naïve Bayesian approaches Re-purposing clinical kinase inhibitors to enhance chemosensitivity by overriding checkpoints Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice.NVP-BEZ235, a dual PI3K/mTOR inhibitor synergistically potentiates the antitumor effects of cisplatin in bladder cancer cells.Targeting DNA repair pathways for cancer treatment: what's new?Combining targeted agents with modern radiotherapy in soft tissue sarcomas.Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro.Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy Radiation Enhancement of Head and Neck Squamous Cell Carcinoma by the Dual PI3K/mTOR Inhibitor PF-05212384.mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.Targeted Inhibition of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Sensitizes Pancreatic Cancer Cells to Doxorubicin without Exacerbating Cardiac Toxicity Inhibition of human positive cofactor 4 radiosensitizes human esophageal squmaous cell carcinoma cells by suppressing XLF-mediated nonhomologous end joining Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 Discovering new mTOR inhibitors for cancer treatment through virtual screening methods and in vitro assays.Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition Cancer subclonal genetic architecture as a key to personalized medicine.Strategies for optimizing the response of cancer and normal tissues to radiation.Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma.Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions.Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in-silico drug-repurposing analysis.Extracellular Vesicles Mediate Radiation-Induced Systemic Bystander Signals in the Bone Marrow and Spleen.Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding.Targeting PI3K in Cancer: Any Good News?The emergence of targeted drugs in breast cancer to prevent resistance to endocrine treatment and chemotherapy.NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor.Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects.Pediatric and adult glioblastoma radiosensitization induced by PI3K/mTOR inhibition causes early metabolic alterations detected by nuclear magnetic resonance spectroscopy.Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma.Simultaneous perturbation of the MAPK and the PI3K/mTOR pathways does not lead to increased radiosensitization.

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The dual PI3K/mTOR inhibitor NVP-BEZ235 is a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage responses.

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Bipasha Mukherjee

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Cristel V Camacho

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Kaushik Amancherla

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Nandini Pichamoorthy

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Nozomi Tomimatsu

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Sandeep Burma

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P2860

NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

Targeting the phosphoinositide 3-kinase pathway in cancer

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining

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