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Modeling Parkinson's disease in primates: The MPTP model

Modeling Parkinson's disease in primates: The MPTP model

http://www.wikidata.org/entity/Q35765748

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Physiological characterisation of human iPS-derived dopaminergic neurons Parkinson's disease: animal models and dopaminergic cell vulnerability The endometrium as a source of mesenchymal stem cells for regenerative medicine Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP(+)-treated Monkeys Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration.The neurobiological basis of cognitive impairment in Parkinson's disease.Da-bu-yin-wan and qian-zheng-san to neuroprotect the mouse model of Parkinson's disease Application of radiosurgical techniques to produce a primate model of brain lesions.A guide to neurotoxic animal models of Parkinson's disease 1-Methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.Animal models of Parkinson's disease: a gateway to therapeutics?Animal models of neurodegenerative diseases.Therapeutic strategies in Parkinson's disease: what we have learned from animal models.Chronic MPTP administration regimen in monkeys: a model of dopaminergic and non-dopaminergic cell loss in Parkinson's disease.Granger causality supports abnormal functional connectivity of beta oscillations in the dorsolateral striatum and substantia nigra pars reticulata in hemiparkinsonian rats.Preclinical Evidence for a Role of the Nicotinic Cholinergic System in Parkinson's Disease.Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques.Behavioral phenotypes associated with MPTP induction of partial lesions in common marmosets (Callithrix jacchus).Dopamine and serotonin modulation of motor and non-motor functions of the non-human primate striato-pallidal circuits in normal and pathological states.Non-human primate models of PD to test novel therapies.Parkinson's disease: Microglial/macrophage-induced immunoexcitotoxicity as a central mechanism of neurodegeneration Early Changes in Saccadic Eye Movement in Hemiparkinsonian MPTP-Treated Monkeys.Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate.Magnetic resonance imaging and tensor-based morphometry in the MPTP non-human primate model of Parkinson's disease.NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients.The Olivary Hypothesis of Essential Tremor: Time to Lay this Model to Rest?Neuroprotective effects of astragaloside IV on Parkinson disease models of mice and primary astrocytes.Knockdown of the mitochondria-localized protein p13 protects against experimental parkinsonism.Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition.Design and synthesis of a MAO-B-selectively activated prodrug based on MPTP: a mitochondria-targeting chemotherapeutic agent for treatment of human malignant gliomas.Tyrosine Hydroxylase, Vesicular Monoamine Transporter and Dopamine Transporter mRNA Expression in Nigrostriatal Tissue of Rats with Pedunculopontine Neurotoxic Lesion.Chronic and progressive Parkinson's disease MPTP model in adult and aged mice.Near-infrared light is neuroprotective in a monkey model of Parkinson disease.Aqueous Extract of Dendropanax morbiferus Leaves Effectively Alleviated Neuroinflammation and Behavioral Impediments in MPTP-Induced Parkinson's Mouse Model.A history of deep brain stimulation: Technological innovation and the role of clinical assessment tools.Charting the onset of Parkinson-like motor and non-motor symptoms in nonhuman primate model of Parkinson's disease

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Modeling Parkinson's disease in primates: The MPTP model

http://www.wikidata.org/entity/Q35765748

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Cold Spring Harbor Perspectives in Medicine

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Modeling Parkinson's disease in primates: The MPTP model

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Gregory Porras

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Qin Li

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P2860

Dopamine transporter binding is unaffected by L-DOPA administration in normal and MPTP-treated monkeys

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

Investigating levodopa-induced dyskinesias in the parkinsonian primate

Neuroanatomical study of the A11 diencephalospinal pathway in the non-human primate

Striatal overexpression of DeltaJunD resets L-DOPA-induced dyskinesia in a primate model of Parkinson disease.

A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.

Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.

Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys.

Lentiviral overexpression of GRK6 alleviates L-dopa-induced dyskinesia in experimental Parkinson's disease.

3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates.

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Parkinson's disease

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