Structure of a heparin-dependent complex of Hedgehog and Ihog.
about
The Hedgehog protein familyThe structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingStructural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila RoboThe mode of Hedgehog binding to Ihog homologues is not conserved across different phylaHedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active SiteAll Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerCrystal structure of a hemojuvelin-binding fragment of neogenin at 1.8ÅThe Immunoglobulin-like Domains 1 and 2 of the Protein Tyrosine Phosphatase LAR Adopt an Unusual Horseshoe-like ConformationStructure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling.Structural insights into proteoglycan-shaped Hedgehog signalingDally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal responseAltered heparan sulfate structure in mice with deleted NDST3 gene function.Smoothened goes molecular: new pieces in the hedgehog signaling puzzleExpanded progenitor populations, vitreo-retinal abnormalities, and Müller glial reactivity in the zebrafish leprechaun/patched2 retinaGenetic and biochemical definition of the Hedgehog receptor.Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway.Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.Glycosaminoglycans of the porcine central nervous systemIhog and Boi are essential for Hedgehog signaling in Drosophila.Ihog and Boi elicit Hh signaling via Ptc but do not aid Ptc in sequestering the Hh ligandNew components of Drosophila leg development identified through genome wide association studiesDampening the signals transduced through hedgehog via microRNA miR-7 facilitates notch-induced tumourigenesis.Boc modifies the holoprosencephaly spectrum of Cdo mutant mice.Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form.Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidaseHedgehogs like it sweet, too.Regulation of Hedgehog signaling by ubiquitination.The Drosophila WIF1 homolog Shifted maintains glypican-independent Hedgehog signaling and interacts with the Hedgehog co-receptors Ihog and Boi.Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and releaseSulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate.Shaping morphogen gradients by proteoglycansPseudo-active sites of protease domains: HGF/Met and Sonic hedgehog signaling in cancer.Presentation counts: microenvironmental regulation of stem cells by biophysical and material cues.Interactions between Hedgehog proteins and their binding partners come into view.Genetic and developmental mechanisms underlying the formation of the Drosophila compound eye.Dual roles of the Cardin-Weintraub motif in multimeric Sonic hedgehog.The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development.Deconstructing the hedgehog pathway in development and disease.Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferationDetergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs.
P2860
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P2860
Structure of a heparin-dependent complex of Hedgehog and Ihog.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Structure of a heparin-dependent complex of Hedgehog and Ihog.
@ast
Structure of a heparin-dependent complex of Hedgehog and Ihog.
@en
type
label
Structure of a heparin-dependent complex of Hedgehog and Ihog.
@ast
Structure of a heparin-dependent complex of Hedgehog and Ihog.
@en
prefLabel
Structure of a heparin-dependent complex of Hedgehog and Ihog.
@ast
Structure of a heparin-dependent complex of Hedgehog and Ihog.
@en
P2093
P2860
P356
P1476
Structure of a heparin-dependent complex of Hedgehog and Ihog.
@en
P2093
Brian V Geisbrecht
Daniel J Leahy
Jason S McLellan
Philip A Beachy
Rodolfo Ghirlando
Shenqin Yao
Xiaoyan Zheng
P2860
P304
17208-17213
P356
10.1073/PNAS.0606738103
P407
P577
2006-10-31T00:00:00Z