about
Integrin-based therapeutics: biological basis, clinical use and new drugsSwing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenClosed headpiece of integrin IIb 3 and its complex with an IIb 3-specific antagonist that does not induce openingStructure-Guided Design of a High-Affinity Platelet Integrin IIb 3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDASBiology and structure of leukocyte β 2 integrins and their role in inflammationSmall molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.Bacitracin reveals a role for multiple thiol isomerases in platelet function.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombusDissolution of pre-existing platelet thrombus by synergistic administration of low concentrations of bifunctional antibodies against β3 integrin.The platelet: life on the razor's edge between hemorrhage and thrombosis.RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarctionRising like the phoenix?Structure-based virtual screening of small-molecule antagonists of platelet integrin αIIbβ3 that do not prime the receptor to bind ligandHistorical perspective and future directions in platelet research.Translating from the rivers of Babylon to the coronary bloodstreamApplication of high-throughput screening to identify a novel alphaIIb-specific small- molecule inhibitor of alphaIIbbeta3-mediated platelet interaction with fibrinogen.αIIbβ3: structure and functionIntegrin αIIbβ3: from discovery to efficacious therapeutic targetA novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.Triple antiplatelet therapy in acute coronary syndromes.Integrin modulators: a patent review.αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating.Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation.The effect of tirofiban on fibrinogen/agonist-induced platelet shape change and aggregation.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Oral GPIIb/IIIa antagonists: what went wrong?
@ast
Oral GPIIb/IIIa antagonists: what went wrong?
@en
type
label
Oral GPIIb/IIIa antagonists: what went wrong?
@ast
Oral GPIIb/IIIa antagonists: what went wrong?
@en
prefLabel
Oral GPIIb/IIIa antagonists: what went wrong?
@ast
Oral GPIIb/IIIa antagonists: what went wrong?
@en
P356
P1476
Oral GPIIb/IIIa antagonists: what went wrong?
@en
P2093
Dermot Cox
P304
P356
10.2174/1381612043384673
P577
2004-01-01T00:00:00Z