Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease - Wikidata - awgldk - TriplyDB

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease

http://www.wikidata.org/entity/Q35773886

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Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement Neuropathology of non-Alzheimer degenerative disorders Novel subcellular localization for α-synuclein: possible functional consequences Multiple system atrophy: a clinical and neuropathological perspective Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders The many faces of α-synuclein: from structure and toxicity to therapeutic target.Identification of novel regulatory genes in development of the avian reproductive tracts.Accumulation of NACP/alpha-synuclein in lewy body disease and multiple system atrophy Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease.Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.Soluble α-synuclein is a novel modulator of Alzheimer's disease pathophysiology.Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders.Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD.Single cell gene expression profiling in Alzheimer's disease.Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.Role of synucleins in Alzheimer's disease.An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells.The role of NAC in amyloidogenesis in Alzheimer's disease.Specific antibodies to soluble alpha-synuclein conformations in intravenous immunoglobulin preparations.Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro.Ser46-Phosphorylated MARCKS Is a Marker of Neurite Degeneration at the Pre-aggregation Stage in PD/DLB Pathology Model Senescent Microglia Induce Disease Related Changes in α-Synuclein Expression and Activity

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P2860

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease

http://www.wikidata.org/entity/Q35773886

description

1996 nî lūn-bûn

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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1996年论文

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name

Altered presynaptic protein NA ...... eration in Alzheimer's disease

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Altered presynaptic protein NA ...... eration in Alzheimer's disease

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Altered presynaptic protein NA ...... eration in Alzheimer's disease

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Altered presynaptic protein NA ...... eration in Alzheimer's disease

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Altered presynaptic protein NA ...... eration in Alzheimer's disease

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The American Journal of Pathology

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Altered presynaptic protein NA ...... eration in Alzheimer's disease

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P2860

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles.

The rat brain synucleins; family of proteins transiently associated with neuronal membrane.

Casein kinase II alteration precedes tau accumulation in tangle formation

Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat.

NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation.

Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels.

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Alzheimer's disease

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1861620

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