Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov
about
Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancerNatural-product sugar biosynthesis and enzymatic glycodiversification.Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.Characterization of the TDP-D-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-D-ravidosamine from thymidine-5-phosphate and glucose-1-phosphate.Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.Structural insight into MtmC, a bifunctional ketoreductase-methyltransferase involved in the assembly of the mithramycin trisaccharide chainNanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGTCrystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus.A comprehensive review of glycosylated bacterial natural products.A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose.Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivityGeneration of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Inactivation of the ketoreductase gilU gene of the gilvocarcin biosynthetic gene cluster yields new analogues with partly improved biological activity.Natural glycoconjugates with antitumor activity.Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.Modification of the antibiotic olivomycin I at the 2'-keto group of the side chain. Novel derivatives, antitumor and topoisomerase I-poisoning activity.Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOIICooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.
P2860
Q28482457-82CE8FA4-19FD-466B-A27C-72C841D518CEQ30492476-B5A0C9D6-2F62-4A85-93E3-B8D7AE30AC10Q33976557-13192AC1-B665-4D87-8B25-5E362EDD887FQ34160676-5F718ECF-2011-4409-B1B1-BCD1ADEDD6CAQ34316021-9C7220D1-DB57-4728-A5F0-C96FB6A940B7Q34497376-07FD8683-3271-4278-BD8A-4A83682A0685Q35528492-F8E2FD6B-30C1-407E-B68D-0ACE104A3BFCQ35556943-D3E130BB-0BF5-4094-AB5D-639DAE83BD1DQ35781141-44E14FAD-332C-4E49-9B26-DF969E0D24ADQ35803683-5797D530-9C51-4730-AAAF-6E50E4F455E9Q35994910-A3F94AC0-7E73-4F7B-BDB8-6D0EB7422BB4Q36029831-309FBE9D-4416-4655-A221-5DC457777095Q36090660-3C815388-3F11-4640-A4AF-749D01541CA8Q36142802-835A9360-1E1E-43DE-A5A3-0ACE5D409424Q36741739-EF838661-EE73-457C-8199-AC512222CAD6Q36953571-C17FDBD7-CF10-4A12-85E6-7E1C6CF3C965Q37186561-5F1D276D-B165-4B7C-B469-5724ED1B7382Q37814157-162BF2D2-91B3-4228-B24F-9CDB6E4CAA24Q37845949-B3B6EFDC-C220-48E0-9052-735A995F9E3AQ39897453-5BD23A34-F7BB-4FB6-A4D6-F82955414279Q42113467-D0DB925D-D825-4D9F-ABA3-07B715EBFD0EQ42915951-38A49C3F-A13F-4CB9-86EA-3DD159270D58Q45265922-6D0C27CB-5829-4548-B9F9-4DF41A1CDA81
P2860
Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Ketopremithramycins and ketomi ...... omyces argillaceus, reveal nov
@ast
Ketopremithramycins and ketomi ...... omyces argillaceus, reveal nov
@en
type
label
Ketopremithramycins and ketomi ...... omyces argillaceus, reveal nov
@ast
Ketopremithramycins and ketomi ...... omyces argillaceus, reveal nov
@en
prefLabel
Ketopremithramycins and ketomi ...... omyces argillaceus, reveal nov
@ast
Ketopremithramycins and ketomi ...... omyces argillaceus, reveal nov
@en
P2093
P2860
P356
P1476
Ketopremithramycins and ketomi ...... omyces argillaceus, reveal nov
@en
P2093
Ana Gonzalez
Daniel W Bearden
Eva Künzel
Jose A Salas
Jose Garcia-Bernardo
Jürgen Rohr
Lily L Remsing
P2860
P304
P356
10.1021/JA0105156
P407
P577
2002-02-01T00:00:00Z