Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells. - Wikidata - awgldk - TriplyDB

Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.

Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.

http://www.wikidata.org/entity/Q35786902

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Regenerative medicine in China: main progress in different fields Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells Gefitinib analogue V1801 induces apoptosis of T790M EGFR-harboring lung cancer cells by up-regulation of the BH-3 only protein Noxa Tumor cells can evade dependence on autophagy through adaptation.Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41.EHHM, a novel phenolic natural product from Livistona chinensis, induces autophagy-related apoptosis in hepatocellular carcinoma cells.Targeted therapy: The new lease on life for acute promyelocytic leukemia, and beyond.AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Celastrol Induces Cell Apoptosis and Inhibits the Expression of the AML1-ETO/C-KIT Oncoprotein in t(8;21) Leukemia.Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis.Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death.

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P2860

Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.

http://www.wikidata.org/entity/Q35786902

description

2012 nî lūn-bûn

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Proceedings of the National Academy of Sciences of the United States of America

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Bortezomib interferes with C-K ...... g fragments in leukemia cells.

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Bo Zhang

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Feng-Xiang Zhang

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Guang-Biao Zhou

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Guo-Qing Sheng

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Hai-Tong Fang

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Hong-Xia Zhao

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Jun Xie

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Li Gao

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Liang Ma

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Sai-Juan Chen

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P2860

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand

Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3

KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation

Targeting the dynamic HSP90 complex in cancer

Dynasore, a cell-permeable inhibitor of dynamin

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

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