Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP.
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Binding Isotherms and Time Courses Readily from Magnetic ResonanceStructural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.Structural Characterization of Interactions between the Double-Stranded RNA-Binding Zinc Finger Protein JAZ and Nucleic AcidsBinding Mechanisms of Intrinsically Disordered Proteins: Theory, Simulation, and ExperimentElectrostatically accelerated encounter and folding for facile recognition of intrinsically disordered proteinsEfficient production of (2)H, (13)C, (15)N-enriched industrial enzyme Rhizopus chinensis lipase with native disulfide bonds.Principal component analysis of chemical shift perturbation data of a multiple-ligand-binding system for elucidation of respective binding mechanism.Tracking Equilibrium and Nonequilibrium Shifts in Data with TREND.Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding.Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Slow, reversible, coupled folding and binding of the spectrin tetramerization domain.Folding and binding of an intrinsically disordered protein: fast, but not 'diffusion-limited'.Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-κB and transcription regulatory factors.The high-risk HPV16 E7 oncoprotein mediates interaction between the transcriptional coactivator CBP and the retinoblastoma protein pRb.The binding mechanisms of intrinsically disordered proteins.Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and foldingThe Fundamental Role of Flexibility on the Strength of Molecular Binding.An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor.NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptorRate constants and mechanisms of intrinsically disordered proteins binding to structured targetsDual-site interactions of p53 protein transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways.Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein.Solution structure of the Z-DNA binding domain of PKR-like protein kinase from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition.Monitoring Ligand-Induced Protein Ordering in Drug Discovery.Solution NMR Spectroscopy in Target-Based Drug Discovery.ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.Conformational recognition of an intrinsically disordered protein.Two-Dimensional NMR Lineshape Analysis.Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization.Using singular value decomposition to characterize protein-protein interactions by in-cell NMR spectroscopy.Mapping the interactions of adenoviral E1A proteins with the p160 nuclear receptor coactivator binding domain of CBP.Globular and disordered-the non-identical twins in protein-protein interactions.Phosphorylation-coupled intramolecular dynamics of unstructured regions in chromatin remodeler FACT.Attachment of norovirus to histo blood group antigens: a cooperative multistep process.Multi-site binding of epigallocatechin gallate to human serum albumin measured by NMR and isothermal titration calorimetry.Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIHThermodynamic and kinetic analysis of peptides derived from CapZ, NDR, p53, HDM2, and HDM4 binding to human S100B
P2860
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P2860
Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Quantitative analysis of multi ...... s with the TAZ2 domain of CBP.
@ast
Quantitative analysis of multi ...... s with the TAZ2 domain of CBP.
@en
type
label
Quantitative analysis of multi ...... s with the TAZ2 domain of CBP.
@ast
Quantitative analysis of multi ...... s with the TAZ2 domain of CBP.
@en
prefLabel
Quantitative analysis of multi ...... s with the TAZ2 domain of CBP.
@ast
Quantitative analysis of multi ...... s with the TAZ2 domain of CBP.
@en
P2860
P50
P356
P1476
Quantitative analysis of multi ...... s with the TAZ2 domain of CBP.
@en
P2860
P304
P356
10.1021/JA209936U
P407
P577
2012-02-15T00:00:00Z