Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. - Wikidata - awgldk - TriplyDB

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

http://www.wikidata.org/entity/Q35792731

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Therapeutic opportunities for targeting the ubiquitous cell surface receptor CD47 Thrombospondin-1 signaling through CD47 inhibits self-renewal by regulating c-Myc and other stem cell transcription factors Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management The genetics of pulmonary arterial hypertension Signaling and stress: The redox landscape in NOS2 biology Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.TGF-β activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension.Forced exercise enhances functional recovery after focal cerebral ischemia in spontaneously hypertensive rats.Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension Age-associated induction of cell membrane CD47 limits basal and temperature-induced changes in cutaneous blood flow.CD47 blockade reduces ischemia-reperfusion injury and improves outcomes in a rat kidney transplant model.CD47 blockade reduces ischemia/reperfusion injury and improves survival in a rat liver transplantation model.Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury.Original insights on thrombospondin-1-related antireceptor strategies in cancer.Peroxisome proliferator-activated receptor gamma (PPARγ) regulates thrombospondin-1 and Nox4 expression in hypoxia-induced human pulmonary artery smooth muscle cell proliferation Association of Plasma Thrombospondin-1 Level with Cardiovascular Disease and Mortality in Hemodialysis Patients.The role of circulating thrombospondin-1 in patients with precapillary pulmonary hypertension Dimethyl Fumarate ameliorates pulmonary arterial hypertension and lung fibrosis by targeting multiple pathways Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease.Invoking the power of thrombospondins: regulation of thrombospondins expression Compartmentalized nitric oxide signaling in the resistance vasculature Thrombospondin-1, free radicals, and the coronary microcirculation: the aging conundrum.Regulation of cellular redox signaling by matricellular proteins in vascular biology, immunology, and cancer Nitric oxide: what's new to NO?Matricellular protein thrombospondin-1 in pulmonary hypertension: multiple pathways to disease.HIF-2α-mediated induction of pulmonary thrombospondin-1 contributes to hypoxia-driven vascular remodelling and vasoconstriction Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase The matricellular protein TSP1 promotes human and mouse endothelial cell senescence through CD47 and Nox1.Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1.Physiological levels of thrombospondin-1 decrease NO-dependent vasodilation in coronary microvessels from aged rats.TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2.MiR-125a regulates mitochondrial homeostasis through targeting mitofusin 1 to control hypoxic pulmonary vascular remodeling.What mediates the effects of thrombospondin-1 in pulmonary hypertension? New evidence for a dual-pronged role of CD47.'Hypoxio-spondin': thrombospondin and its emerging role in pulmonary hypertension.Rare variants in RNF213, a susceptibility gene for moyamoya disease, are found in patients with pulmonary hypertension and aggravate hypoxia-induced pulmonary hypertension in mice.

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P2860

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

http://www.wikidata.org/entity/Q35792731

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Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

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Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

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Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

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Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

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Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

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Cardiovascular Research

P1476

Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1.

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Brian S Zuckerbraun

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Eileen M Bauer

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Hunter C Champion

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Jeffrey S Isenberg

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Joseph M Pilewski

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Maria J Calzada

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Mingyi Yao

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Monica Feijoo-Cuaresma

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Natasha M Rogers

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Philip M Bauer

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P2860

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

Signal transduction of eNOS activation

Aspirin induces nitric oxide release from vascular endothelium: a novel mechanism of action

Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity

CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1

Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice

Clinical classification of pulmonary hypertension.

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10.1093/CVR/CVR356

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4

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93

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51981331

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22215724

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3291089

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