Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors. - Wikidata - awgldk - TriplyDB

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.

http://www.wikidata.org/entity/Q35797589

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Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes Functions of TET Proteins in Hematopoietic Transformation Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation Engineering mouse models with myelodysplastic syndrome human candidate genes; how relevant are they?Connections between TET proteins and aberrant DNA modification in cancer The TET2 interactors and their links to hematological malignancies Role of TET enzymes in DNA methylation, development, and cancer DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice LC-MS-MS quantitative analysis reveals the association between FTO and DNA methylation Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis.TET proteins and the control of cytosine demethylation in cancer.TET family proteins and their role in stem cell differentiation and transformation.Tet family proteins and 5-hydroxymethylcytosine in development and disease Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma.TET proteins and 5-methylcytosine oxidation in hematological cancers Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia.Myeloid-derived suppressor cells inhibit T cell proliferation in human extranodal NK/T cell lymphoma: a novel prognostic indicator.Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.DNA methylation and hydroxymethylation in hematologic differentiation and transformation.Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms.2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.Interplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes.The hypomethylating agent Decitabine causes a paradoxical increase in 5-hydroxymethylcytosine in human leukemia cells Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia.Alterations of 5-hydroxymethylcytosine in human cancers.An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis.Characterization of TET and IDH gene expression in chronic lymphocytic leukemia: comparison with normal B cells and prognostic significance TET2 plays an essential role in erythropoiesis by regulating lineage-specific genes via DNA oxidative demethylation in a zebrafish model.5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia.Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells Chromatographic methods for the analysis of oxidatively damaged DNA.An evolutionary perspective on chronic myelomonocytic leukemia.Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia.5-hydroxymethylcytosine: a new insight into epigenetics in cancer.5-hydroxymethylcytosine: a potential therapeutic target in cancer.Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways.

P2860

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P2860

Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.

http://www.wikidata.org/entity/Q35797589

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Inhibition of TET2-mediated co ...... man hematopoietic progenitors.

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Inhibition of TET2-mediated co ...... man hematopoietic progenitors.

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Aline Massé

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Aparna Vasanthakumar

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Audrey Simon

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Barbara da Costa Reis Monte Mor

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Bruno Carbonne

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Carole Almire

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Elodie Pronier

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François Delhommeau

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Frédéric Pendino

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Hayat Mokrani

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P2860

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

DNMT3A Mutations in Acute Myeloid Leukemia

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

Mutation in TET2 in myeloid cancers

Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry.

Acquired mutations in TET2 are common in myelodysplastic syndromes.

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