Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.
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Biomarkers of Nutrition for Development-Folate ReviewModeling cellular compartmentation in one-carbon metabolismHow pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric stateAn active second dihydrofolate reductase enzyme is not a feature of rat and mouse, but they do have activity in their mitochondriaPlasma homocysteine levels and genetic polymorphisms in folate metablism are associated with breast cancer risk in chinese women.A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesisAzoxymethane-induced colon carcinogenesis in mice occurs independently of de novo thymidylate synthesis capacity.Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles in Drosophila.Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiencyTranscriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression.SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.The contribution of CMP kinase to the efficiency of DNA repaircMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.Aldehyde dehydrogenase homologous folate enzymes: Evolutionary switch between cytoplasmic and mitochondrial localization.miR-370 and miR-373 regulate the pathogenesis of osteoarthritis by modulating one-carbon metabolism via SHMT-2 and MECP-2, respectivelyDihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation.New insights into the metabolic and nutritional determinants of severe combined immunodeficiency.G-protein-coupled receptor regulation of de novo purine biosynthesis: a novel druggable mechanism.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation.Deoxyribonucleotide metabolism, mutagenesis and cancer.One-carbon metabolism in cancer.miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma.Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.One-Carbon Metabolism in Health and Disease.Targeting nuclear thymidylate biosynthesis.Computational modelling folate metabolism and DNA methylation: implications for understanding health and ageing.Folate nutrition and blood-brain barrier dysfunction.The Roles of SUMO in Metabolic Regulation.Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.Arsenic trioxide targets MTHFD1 and SUMO-dependent nuclear de novo thymidylate biosynthesis.MTHFD1 regulates nuclear de novo thymidylate biosynthesis and genome stability.Sensitizing cancer cells: is it really all about U?Folate rescues vitamin B12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability.Synthesis and Physicochemical Characterization of the One-Carbon Carrier 10-Formyltetrahydrofolate; A Reference Standard for Metabolomics.Human dihydrofolate reductase and thymidylate synthase form a complex in vitro and co-localize in normal and cancer cells.Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translationIntegrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact
P2860
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P2860
Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Serine hydroxymethyltransferas ...... lear lamina for DNA synthesis.
@ast
Serine hydroxymethyltransferas ...... lear lamina for DNA synthesis.
@en
type
label
Serine hydroxymethyltransferas ...... lear lamina for DNA synthesis.
@ast
Serine hydroxymethyltransferas ...... lear lamina for DNA synthesis.
@en
prefLabel
Serine hydroxymethyltransferas ...... lear lamina for DNA synthesis.
@ast
Serine hydroxymethyltransferas ...... lear lamina for DNA synthesis.
@en
P2093
P2860
P356
P1476
Serine hydroxymethyltransferas ...... lear lamina for DNA synthesis.
@en
P2093
Barry Shane
Collynn F Woeller
Donald D Anderson
En-Pei Chiang
Patrick J Stover
P2860
P304
P356
10.1074/JBC.M111.333120
P407
P577
2012-01-10T00:00:00Z