Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling
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The Role of Toll-Like Receptors in Hematopoietic MalignanciesUbiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.The genetics of myelodysplastic syndrome: from clonal haematopoiesis to secondary leukaemiaKnockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells.Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemiaHaploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms.MiR-146 and miR-125 in the regulation of innate immunity and inflammation.TRAF6 regulates the effects of polarized maturation of tolerability: Marrow-derived dendritic cells on collagen-induced arthritis in mice.Therapy-related myeloid neoplasms: when genetics and environment collide.β-Catenin Is a Candidate Therapeutic Target for Myeloid Neoplasms with del(5q).MiR-146a/b: a family with shared seeds and different roots.Constitutive Activation of NIK Impairs the Self-Renewal of Hematopoietic Stem/Progenitor Cells and Induces Bone Marrow Failure.miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression.Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.Inflammatory Signaling Pathways in Preleukemic and Leukemic Stem Cells.Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.MicroRNAs as New Biomarkers for Diagnosis and Prognosis, and as Potential Therapeutic Targets in Acute Myeloid Leukemia.TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis.Loss of toll-like receptor 2 results in accelerated leukemogenesis in the NUP98-HOXD13 mouse model of MDS.Chronic innate immune signaling results in ubiquitination of splicing machinery.Age-related inflammatory bone marrow microenvironment induces ineffective erythropoiesis mimicking del(5q) MDS.miR-146 and miR-155: Two Key Modulators of Immune Response and Tumor Development.Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-κB Activation in Human Myeloid Leukemia THP-1 Cells.Targeting age-related inflammation in myelodysplastic syndromes
P2860
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P2860
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling
description
2015 nî lūn-bûn
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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2015年论文
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2015年论文
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name
Loss of Tifab, a del(5q) MDS g ...... -like receptor-TRAF6 signaling
@ast
Loss of Tifab, a del(5q) MDS g ...... -like receptor-TRAF6 signaling
@en
type
label
Loss of Tifab, a del(5q) MDS g ...... -like receptor-TRAF6 signaling
@ast
Loss of Tifab, a del(5q) MDS g ...... -like receptor-TRAF6 signaling
@en
prefLabel
Loss of Tifab, a del(5q) MDS g ...... -like receptor-TRAF6 signaling
@ast
Loss of Tifab, a del(5q) MDS g ...... -like receptor-TRAF6 signaling
@en
P2093
P2860
P356
P1476
Loss of Tifab, a del(5q) MDS g ...... -like receptor-TRAF6 signaling
@en
P2093
Aly Karsan
Andres Jerez
Daniel T Starczynowski
David Miller
Hiroyasu Konno
Jaroslaw P Maciejewski
Jun-ichiro Inoue
Madeline Niederkorn
P2860
P304
P356
10.1084/JEM.20141898
P407
P577
2015-10-12T00:00:00Z