Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53. - Wikidata - awgldk - TriplyDB

Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

http://www.wikidata.org/entity/Q35804653

about

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma The Modulation of Apoptotic Pathways by Gammaherpesviruses The Contrived Mutant p53 Oncogene - Beyond Loss of Functions Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness Nuclear actions of insulin-like growth factor binding protein-3 Mutant p53 gain-of-function in cancer.KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.Apoptosis in cancer: from pathogenesis to treatment.The proline TP53 variant stimulates likely lymphangiogenesis in an orthotopic mouse model of pancreatic cancer.Mitochondrial dysfunction in cancer.Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage.Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells.Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis.Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities.Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cells The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1.Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage.Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations.Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme.Mutant p53 in cancer: new functions and therapeutic opportunities.Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 status Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis.p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells.Exploiting the p53 Pathway for Therapy.Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status.Inhibitory effects of antagonists of growth hormone releasing hormone on experimental prostate cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins.DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells.Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition.GADD45A expression is correlated with patient prognosis in esophageal cancer.

P2860

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P2860

Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

http://www.wikidata.org/entity/Q35804653

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Cancer-derived p53 mutants sup ...... ain of function of mutant p53.

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Cancer-derived p53 mutants sup ...... ain of function of mutant p53.

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type

label

Cancer-derived p53 mutants sup ...... ain of function of mutant p53.

@ast

Cancer-derived p53 mutants sup ...... ain of function of mutant p53.

@en

prefLabel

Cancer-derived p53 mutants sup ...... ain of function of mutant p53.

@ast

Cancer-derived p53 mutants sup ...... ain of function of mutant p53.

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P1433

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P1433

Nucleic Acids Research

P1476

Cancer-derived p53 mutants sup ...... gain of function of mutant p53

@en

P2093

Faina Vikhanskaya

http://www.w3.org/2001/XMLSchema#string

Kanaga Sabapathy

http://www.w3.org/2001/XMLSchema#string

Marco Mazzoletti

http://www.w3.org/2001/XMLSchema#string

Ming Kei Lee

http://www.w3.org/2001/XMLSchema#string

P2860

Mdm2 promotes the rapid degradation of p53

Mutant p53 proteins bind DNA in a DNA structure-selective mode

Regulation of p53 stability by Mdm2

A system for stable expression of short interfering RNAs in mammalian cells

Surfing the p53 network

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants

p53-independent induction of Gadd45 by histone deacetylase inhibitor: coordinate regulation by transcription factors Oct-1 and NF-Y

Live or let die: the cell's response to p53

p300/CBP proteins: HATs for transcriptional bridges and scaffolds

P304

2093-2104

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scholarly article

P356

10.1093/NAR/GKM099

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P407

P433

6

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P478

35

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P50

Massimo Broggini

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2007-03-07T00:00:00Z

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P5875

6463139

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17344317

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1874625

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