Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.
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p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinomaThe Modulation of Apoptotic Pathways by GammaherpesvirusesThe Contrived Mutant p53 Oncogene - Beyond Loss of FunctionsEmerging Non-Canonical Functions and Regulation by p53: p53 and StemnessNuclear actions of insulin-like growth factor binding protein-3Mutant p53 gain-of-function in cancer.KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signalingInvolvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cellsPreferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistanceEvolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.Apoptosis in cancer: from pathogenesis to treatment.The proline TP53 variant stimulates likely lymphangiogenesis in an orthotopic mouse model of pancreatic cancer.Mitochondrial dysfunction in cancer.Amino-terminal p53 mutations lead to expression of apoptosis proficient p47 and prognosticate better survival, but predispose to tumorigenesis.Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.Histone modifications affect differential regulation of TGFβ- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53.Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage.Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells.Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cellsTargeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis.Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities.Targeting mutant p53 by a SIRT1 activator YK-3-237 inhibits the proliferation of triple-negative breast cancer cellsThe DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesisAllyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoterSILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1.Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage.Heterogeneity of Li-Fraumeni syndrome links to unequal gain-of-function effects of p53 mutations.Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme.Mutant p53 in cancer: new functions and therapeutic opportunities.Sensitivity to PRIMA-1MET is associated with decreased MGMT in human glioblastoma cells and glioblastoma stem cells irrespective of p53 statusTranscriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53.Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis.p53siRNA therapy reduces cell proliferation, migration and induces apoptosis in triple negative breast cancer cells.Exploiting the p53 Pathway for Therapy.Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status.Inhibitory effects of antagonists of growth hormone releasing hormone on experimental prostate cancers are associated with upregulation of wild-type p53 and decrease in p21 and mutant p53 proteins.DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells.Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition.GADD45A expression is correlated with patient prognosis in esophageal cancer.
P2860
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P2860
Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Cancer-derived p53 mutants sup ...... ain of function of mutant p53.
@ast
Cancer-derived p53 mutants sup ...... ain of function of mutant p53.
@en
type
label
Cancer-derived p53 mutants sup ...... ain of function of mutant p53.
@ast
Cancer-derived p53 mutants sup ...... ain of function of mutant p53.
@en
prefLabel
Cancer-derived p53 mutants sup ...... ain of function of mutant p53.
@ast
Cancer-derived p53 mutants sup ...... ain of function of mutant p53.
@en
P2093
P2860
P356
P1476
Cancer-derived p53 mutants sup ...... gain of function of mutant p53
@en
P2093
Faina Vikhanskaya
Kanaga Sabapathy
Marco Mazzoletti
Ming Kei Lee
P2860
P304
P356
10.1093/NAR/GKM099
P407
P577
2007-03-07T00:00:00Z