Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
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Two independent positive feedbacks and bistability in the Bcl-2 apoptotic switchModeling a snap-action, variable-delay switch controlling extrinsic cell deathGradient descent optimization in gene regulatory pathwaysSTL-based analysis of TRAIL-induced apoptosis challenges the notion of type I/type II cell line classificationDynamical systems analysis of mitochondrial BAK activation kinetics predicts resistance to BH3 domains.Modeling the role of p53 pulses in DNA damage- induced cell death decision.Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer.From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine.Dynamic modelling of oestrogen signalling and cell fate in breast cancer cellsProgramming biological models in Python using PySBModeling dynamics of cell-to-cell variability in TRAIL-induced apoptosis explains fractional killing and predicts reversible resistanceBMSCs reduce rat granulosa cell apoptosis induced by cisplatin and perimenopause.Data-driven modeling of SRC control on the mitochondrial pathway of apoptosis: implication for anticancer therapy optimization.Measuring and modeling apoptosis in single cells.Bayesian parameter inference by Markov chain Monte Carlo with hybrid fitness measures: theory and test in apoptosis signal transduction networkSteady states and dynamics of urokinase-mediated plasmin activation in silico and in vitroCoordination of the nuclear and cytoplasmic activities of p53 in response to DNA damageMutation-induced protein interaction kinetics changes affect apoptotic network dynamic properties and facilitate oncogenesis.Computational modeling of signaling pathways mediating cell cycle checkpoint control and apoptotic responses to ionizing radiation-induced DNA damage.Signaling cascades transmit information downstream and upstream but unlikely simultaneously.Plasmin triggers a switch-like decrease in thrombospondin-dependent activation of TGF-β1.Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death.Monte carlo study elucidates the type 1/type 2 choice in apoptotic death signaling in healthy and cancer cells.Mathematical modeling of apoptosis.Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.Cholesterol effects on BAX pore activation.Rigor of cell fate decision by variable p53 pulses and roles of cooperative gene expression by p53.Properties of cell death models calibrated and compared using Bayesian approaches.Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch.A cellular stress-directed bistable switch controls the crosstalk between autophagy and apoptosis.Theoretical Analysis of Fas Ligand-Induced Apoptosis with an Ordinary Differential Equation Model.
P2860
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P2860
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
@ast
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
@en
type
label
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
@ast
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
@en
prefLabel
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
@ast
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
@en
P2093
P2860
P1433
P1476
Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision
@en
P2093
P2860
P304
P356
10.1529/BIOPHYSJ.106.099606
P407
P50
P577
2007-03-30T00:00:00Z