The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. - Wikidata - awgldk - TriplyDB

The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

http://www.wikidata.org/entity/Q35813751

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Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.Betacellulin inhibits osteogenic differentiation and stimulates proliferation through HIF-1alpha The hypoxia-inducible factor pathway, prolyl hydroxylase domain protein inhibitors, and their roles in bone repair and regeneration Biomaterial delivery of morphogens to mimic the natural healing cascade in bone Hypoxia-inducible factors in physiology and medicine Mesenchymal progenitors and the osteoblast lineage in bone marrow hematopoietic niches Angiogenesis and intramembranous osteogenesis Hypoxic regulation of osteoclast differentiation and bone resorption activity From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation Parathyroid hormone signaling through low-density lipoprotein-related protein 6 Hypoxia-inducible factor-1α protein negatively regulates load-induced bone formation Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects Contemporary Approaches for Identifying Rare Bone Disease Causing Genes.Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor.Prospects for osteoprogenitor stem cells in fracture repair and osteoporosis Angiogenesis in bone regeneration.A physical mechanism for coupling bone resorption and formation in adult human bone.Blood flow controls bone vascular function and osteogenesis.A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.The bone marrow at the crossroads of blood and immunity Glucocorticoids, osteocytes, and skeletal fragility: the role of bone vascularity.Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation Osteoblast-secreted factors promote proliferation and osteogenic differentiation of bone marrow stromal cells via VEGF/heme-oxygenase-1 pathway.Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice.Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling.EPO promotes bone repair through enhanced cartilaginous callus formation and angiogenesis Healing of non-displaced fractures produced by fatigue loading of the mouse ulna.What old means to bone.Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis.Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice.Hypoxia inhibits osteogenesis in human mesenchymal stem cells through direct regulation of RUNX2 by TWIST In vitro model of vascularized bone: synergizing vascular development and osteogenesis Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4 A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice.Icaritin, an exogenous phytomolecule, enhances osteogenesis but not angiogenesis--an in vitro efficacy study

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The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

http://www.wikidata.org/entity/Q35813751

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Chao Wan

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Ernestina Schipani

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Lianfu Deng

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Marie-Claude Faugere

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Mary L Bouxsein

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Robert E Guldberg

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Shawn R Gilbert

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Thomas L Clemens

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Volker H Haase

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Ximeng Liu

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

Molecular basis of the VHL hereditary cancer syndrome

Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

VEGF expression in an osteoblast-like cell line is regulated by a hypoxia response mechanism

Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes

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1616-1626

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10.1172/JCI31581

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6

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117

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Randall S. Johnson

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17549257

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1878533

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