Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.
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Mechanisms of acetaminophen-induced liver necrosisSite-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for 'ping pong' kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abParadoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsHumanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdoseMice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicityIncreased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase PiIntegrative analysis of proteomic and transcriptomic data for identification of pathways related to simvastatin-induced hepatotoxicity.Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.Mice lacking three Loci encoding 14 glutathione transferase genes: a novel tool for assigning function to the GSTP, GSTM, and GSTT families.Rapid dopaminergic modulation of the fish hypothalamic transcriptome and proteome.Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in micePrenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort.Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicityIn vivo regulation of human glutathione transferase GSTP by chemopreventive agents.Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity.Is nuclear factor erythroid 2-related factor 2 responsible for sex differences in susceptibility to acetaminophen-induced hepatotoxicity in mice?Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.NAD(P)H:quinone oxidoreductase (NQO1) polymorphism, exposure to benzene, and predisposition to disease: a HuGE review.Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer.Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1.Toxicogenomics: an opportunity to optimise drug development and safety evaluation.Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice.Role of gene knockout and transgenic mice in the study of xenobiotic metabolism.3,5,5-trimethyl-hexanoyl-ferrocene diet protects mice from moderate transient acetaminophen-induced hepatotoxicity.Hydroxyethyl disulfide as an efficient metabolic assay for cell viability in vitro.Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition.Drug bioactivation, covalent binding to target proteins and toxicity relevance.Idiosyncratic drug hepatotoxicity.Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxificationCarbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.GSTP1 Loss results in accumulation of oxidative DNA base damage and promotes prostate cancer cell survival following exposure to protracted oxidative stressRole of innate immunity in acetaminophen-induced hepatotoxicity.Overexpression of Aldose Reductase Render Mouse Hepatocytes More Sensitive to Acetaminophen Induced Oxidative Stress and Cell Death.The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-The use of glutathione transferase-knockout mice as pharmacological and toxicological models.Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats.Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma.Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity.Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1.
P2860
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P2860
Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Increased resistance to acetam ...... glutathione S-transferase Pi.
@ast
Increased resistance to acetam ...... glutathione S-transferase Pi.
@en
type
label
Increased resistance to acetam ...... glutathione S-transferase Pi.
@ast
Increased resistance to acetam ...... glutathione S-transferase Pi.
@en
prefLabel
Increased resistance to acetam ...... glutathione S-transferase Pi.
@ast
Increased resistance to acetam ...... glutathione S-transferase Pi.
@en
P2093
P2860
P356
P1476
Increased resistance to acetam ...... glutathione S-transferase Pi.
@en
P2093
P2860
P304
12741-12745
P356
10.1073/PNAS.220176997
P407
P577
2000-11-01T00:00:00Z