In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.

In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.

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http://www.wikidata.org/entity/Q35827931
Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control.Conditional gene expression in the mouse inner ear using Cre-loxP.Canonical Notch signaling plays an instructive role in auditory supporting cell development.Sox2-CreER mice are useful for fate mapping of mature, but not neonatal, cochlear supporting cells in hair cell regeneration studies.Auditory hair cell-specific deletion of p27Kip1 in postnatal mice promotes cell-autonomous generation of new hair cells and normal hearing.Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochleaIn vivo visualization of Notch1 proteolysis reveals the heterogeneity of Notch1 signaling activity in the mouse cochlea.Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells.Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expressionRegulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium.Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochleaNotch signaling during cell fate determination in the inner ear.Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelinationEctopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear.Hypoxia-NOTCH1-SOX2 signaling is important for maintaining cancer stem cells in ovarian cancer.
P2860

In vivo Notch reactivation in differentiating cochlear hair cells induces Sox2 and Prox1 expression but does not disrupt hair cell maturation.

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http://www.wikidata.org/entity/Q35827931
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2012 nî lūn-bûn
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2012年の論文
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2012年論文
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2012年論文
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name
In vivo Notch reactivation in ...... disrupt hair cell maturation.
@ast
In vivo Notch reactivation in ...... disrupt hair cell maturation.
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type
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In vivo Notch reactivation in ...... disrupt hair cell maturation.
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In vivo Notch reactivation in ...... disrupt hair cell maturation.
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In vivo Notch reactivation in ...... disrupt hair cell maturation.
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In vivo Notch reactivation in ...... disrupt hair cell maturation.
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In vivo Notch reactivation in ...... disrupt hair cell maturation.
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P2093
P2860
P304
P31
P356
P433
P478
P577
P698
P932