Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors.
about
Ten things you should know about protein kinases: IUPHAR Review 14Bivalent inhibitors of protein kinasesConversion of a Single Polypharmacological Agent into Selective Bivalent Inhibitors of Intracellular Kinase ActivityDivergent modulation of Src-family kinase regulatory interactions with ATP-competitive inhibitors.The ins and outs of selective kinase inhibitor development.A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.Label transfer reagents to probe p38 MAPK binding partnersExamining the influence of specificity ligands and ATP-competitive ligands on the overall effectiveness of bivalent kinase inhibitors.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.
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P2860
Targeting diverse signaling interaction sites allows the rapid generation of bivalent kinase inhibitors.
description
2011 nî lūn-bûn
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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name
Targeting diverse signaling in ...... of bivalent kinase inhibitors.
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Targeting diverse signaling in ...... of bivalent kinase inhibitors.
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Targeting diverse signaling in ...... of bivalent kinase inhibitors.
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Targeting diverse signaling in ...... of bivalent kinase inhibitors.
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Targeting diverse signaling in ...... of bivalent kinase inhibitors.
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Targeting diverse signaling in ...... of bivalent kinase inhibitors.
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P2093
P2860
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Targeting diverse signaling in ...... of bivalent kinase inhibitors.
@en
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B Gayani K Perera
Dustin J Maly
Simeon S Andrews
Zachary B Hill
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P304
P356
10.1021/CB200387G
P577
2011-12-22T00:00:00Z