Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
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Mutant p53 Drives Cancer by Subverting Multiple Tumor Suppression PathwaysThe Nrf2/HO-1 Axis in Cancer Cell Growth and ChemoresistanceHER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interactionComparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell lineThe Keap1-Nrf2 system in cancers: stress response and anabolic metabolismThe Keap1-Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases.Regulation of Nrf2 signaling and longevity in naturally long-lived rodents.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.The emerging role of the Nrf2-Keap1 signaling pathway in cancerCancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitinationMonitoring Keap1-Nrf2 interactions in single live cells.Molecular and chemical regulation of the Keap1-Nrf2 signaling pathway.Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell LinesIdentification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination.WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense.Binding of disordered proteins to a protein hub.Comparison of Secondary Structure Formation Using 10 Different Force Fields in Microsecond Molecular Dynamics Simulations.Transcriptional Regulation by Nrf2.The Role of Nrf2 in Cardiovascular Function and Disease.¹H, ¹⁵N and ¹³C backbone resonance assignments of the Kelch domain of mouse Keap1.CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells.Molecular effects of cancer-associated somatic mutations on the structural and target recognition properties of Keap1.Dysregulation of NRF2 in Cancer: from Molecular Mechanisms to Therapeutic Opportunities.A knock-in mouse line conditionally expressing the tumor suppressor WTX/AMER1.Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy.Keap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoaSevere osteopathia striata with cranial sclerosis in a female case with wholeWTXgene deletion
P2860
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P2860
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Wilms tumor gene on X chromoso ...... tive binding to KEAP1 protein.
@ast
Wilms tumor gene on X chromoso ...... tive binding to KEAP1 protein.
@en
type
label
Wilms tumor gene on X chromoso ...... tive binding to KEAP1 protein.
@ast
Wilms tumor gene on X chromoso ...... tive binding to KEAP1 protein.
@en
prefLabel
Wilms tumor gene on X chromoso ...... tive binding to KEAP1 protein.
@ast
Wilms tumor gene on X chromoso ...... tive binding to KEAP1 protein.
@en
P2093
P2860
P356
P1476
Wilms tumor gene on X chromoso ...... tive binding to KEAP1 protein.
@en
P2093
David W Dawson
James M Davison
Michael B Major
Nathan D Camp
Ning Zheng
Randall T Moon
Richard G James
Scott A Houck
Xiaobo Tang
P2860
P304
P356
10.1074/JBC.M111.316471
P407
P577
2012-01-03T00:00:00Z