EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. - Wikidata - awgldk - TriplyDB

EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

http://www.wikidata.org/entity/Q35839517

about

An autism-associated variant of Epac2 reveals a role for Ras/Epac2 signaling in controlling basal dendrite maintenance in mice Role of EPAC in cAMP-Mediated Actions in Adrenocortical Cells Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).Deletion of Rapgef6, a candidate schizophrenia susceptibility gene, disrupts amygdala function in mice.Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection Prostanoid receptor EP2 as a therapeutic target Adult-specific functions of animal microRNAs.Isoform-specific antagonists of exchange proteins directly activated by cAMP Enhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1 The future of EPAC-targeted therapies: agonism versus antagonism DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms Cannabinoid type 1 receptors transiently silence glutamatergic nerve terminals of cultured cerebellar granule cells.Epac activation initiates associative odor preference memories in the rat pup.Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery.Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.An updated role of microRNA-124 in central nervous system disorders: a review.Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility.Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling.MicroRNA miR124 is required for the expression of homeostatic synaptic plasticity.Social, communication, and cortical structural impairments in Epac2-deficient mice.A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau.MicroRNA-276a functions in ellipsoid body and mushroom body neurons for naive and conditioned olfactory avoidance in Drosophila.Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area.An Aplysia Egr homolog is rapidly and persistently regulated by long-term sensitization training.NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons.Epac2 contributes to PACAP-induced astrocytic differentiation through calcium ion influx in neural precursor cells Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros.β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice.EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability.Satb2 determines miRNA expression and long-term memory in the adult central nervous system.MicroRNAs regulate neuronal plasticity and are involved in pain mechanisms.Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance.The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders.MicroRNAs shape the neuronal landscape.Dendritic spines: the locus of structural and functional plasticity.cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).A-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.MicroRNAs and synaptic plasticity--a mutual relationship

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P2860

EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

http://www.wikidata.org/entity/Q35839517

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

EPAC null mutation impairs lea ...... iR-124 and Zif268 translation.

@ast

EPAC null mutation impairs lea ...... iR-124 and Zif268 translation.

@en

type

label

EPAC null mutation impairs lea ...... iR-124 and Zif268 translation.

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EPAC null mutation impairs lea ...... iR-124 and Zif268 translation.

@en

prefLabel

EPAC null mutation impairs lea ...... iR-124 and Zif268 translation.

@ast

EPAC null mutation impairs lea ...... iR-124 and Zif268 translation.

@en

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J.NEURON.2012.02.003

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P1476

EPAC null mutation impairs lea ...... iR-124 and Zif268 translation.

@en

P2093

Dan Liu

http://www.w3.org/2001/XMLSchema#string

Jian Zhang

http://www.w3.org/2001/XMLSchema#string

Jian-Zhi Wang

http://www.w3.org/2001/XMLSchema#string

Kun Qian

http://www.w3.org/2001/XMLSchema#string

Lei Pei

http://www.w3.org/2001/XMLSchema#string

Ling-Qiang Zhu

http://www.w3.org/2001/XMLSchema#string

Qing Tian

http://www.w3.org/2001/XMLSchema#string

Ronald S Petralia

http://www.w3.org/2001/XMLSchema#string

Weihong Tu

http://www.w3.org/2001/XMLSchema#string

Xiaogang Shu

http://www.w3.org/2001/XMLSchema#string

P2860

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

A family of cAMP-binding proteins that directly activate Rap1

The Autistic Neuron: Troubled Translation?

Autism and brain development

A synaptic model of memory: long-term potentiation in the hippocampus

Synaptic AMPA receptor plasticity and behavior.

The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development

A functional study of miR-124 in the developing neural tube

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction

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774-788

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scholarly article

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10.1016/J.NEURON.2012.02.003

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4

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73

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2012-02-01T00:00:00Z

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221861852

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22365550

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3307595

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