Isoform-specific antagonists of exchange proteins directly activated by cAMP
about
Structure-guided design of selective Epac1 and Epac2 agonistsCardiac cAMP: production, hydrolysis, modulation and detectionStructural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMPThe central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytesExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsRecent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC).A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasionEnhanced leptin sensitivity, reduced adiposity, and improved glucose homeostasis in mice lacking exchange protein directly activated by cyclic AMP isoform 1Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsiosesCyclic AMP sensor EPAC proteins and energy homeostasis.Blocking of exchange proteins directly activated by cAMP leads to reduced replication of Middle East respiratory syndrome coronavirus.The future of EPAC-targeted therapies: agonism versus antagonismBiochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".Circadian rhythms. A protein fold switch joins the circadian oscillator to clock output in cyanobacteria.Identification and characterization of small molecules as potent and specific EPAC2 antagonists.Activators of PKA and Epac distinctly influence insulin secretion and cytosolic Ca2+ in female mouse islets stimulated by glucose and tolbutamide.Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling.Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1.The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.Efficient Synthesis of ESI-09, A Novel Non-cyclic Nucleotide EPAC AntagonistExchange protein directly activated by cAMP modulates regulatory T-cell-mediated immunosuppressionFunctionalized N,N-Diphenylamines as Potent and Selective EPAC2 Inhibitors.Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.Increased microvascular permeability in mice lacking Epac1 (Rapgef3).Inhibition of Epac1 suppresses mitochondrial fission and reduces neointima formation induced by vascular injury.Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3.cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation.Epac proteins: specific ligands and role in cardiac remodelling.New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout miceA-kinase anchoring proteins: cAMP compartmentalization in neurodegenerative and obstructive pulmonary diseases.Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.The role of Epac in the heart.Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition.Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias.Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue.Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin ActionsA cell-based, quantitative and isoform-specific assay for exchange proteins directly activated by cAMP.
P2860
Q21145700-A2DD6C05-10B4-4651-8955-7DD024837E3AQ26781612-61532623-28B7-47D2-A7C1-9CAADFD3497BQ27675290-8D21B6E0-4002-4BC7-B46A-1CB5A7BE17A0Q27974567-33462015-D956-4847-B21D-4DEF7B17D349Q28608179-C4BE7E87-9342-45B8-BA94-4022BE7A99C3Q30405298-1C00D981-A184-48D2-B50A-9A29C1CBF654Q34306163-0A47B163-2222-4078-BCF5-9BC81C1955F2Q34319327-77C71690-9F06-4151-8F13-7D0CA7F4F1E1Q34384331-649DAF8F-F46B-4A59-A65C-2E02B091A168Q34385094-A3DA9EC0-3F6C-49CC-98AF-34EE76A8AF88Q34399575-E4BBD96F-FD90-4029-99F3-C71608024B99Q34465923-A58214C5-60A8-4E47-8938-3984EC301DF9Q34467944-7CF8EDA1-471E-4B50-905C-94C2A8C0AEC1Q34482461-E22B50A8-A40E-490B-A5D0-5852A7D7C9BFQ34535973-BAAA704F-D031-4631-AB67-745B38632715Q34628129-337361F4-890D-43E0-8E0F-4DCD91A505C9Q35794969-9F75D26A-8554-46BF-934B-9A76A60314FBQ36094185-D4D3DC94-1248-4EB5-876D-3BF3361B7CA9Q36319044-D8BED3E1-5166-48EB-8B78-C09F80CCDDFBQ36398745-36689AE1-A6A1-4AD1-8EB5-69CEC28E4989Q36624204-794CD55B-EAB7-4B72-AA7F-3DF0693EE465Q36634333-15470DBA-09A4-4C0F-9D7B-E2601AF0CB6DQ36635113-8B6EDC0A-C741-4FFF-A4E0-018461ECF644Q36902839-D893C15A-9443-4879-B549-2D55B7B50F22Q37050355-10F056B9-8811-4966-AA55-3697D316BAF3Q37354927-6A9C865F-DF6E-48A0-BF66-9C541E195A76Q37405587-0BA6F441-73FD-4D85-BC3A-BA76351F7E47Q37604194-AC2093A5-35C2-4F7C-B65B-D3AE54CBA7AAQ38180763-6BE2B680-0674-465D-9A39-8325E646CB91Q38184156-39A312F0-29A2-4605-8536-909487155476Q38197308-58B129E6-76C9-4353-90A8-45CD14EE2684Q38224884-5D20E832-DFB2-4349-BD68-3ECBFC02515DQ38240756-547A3891-750B-4273-A912-F31A5A40ED63Q38747476-7DFC6FF5-8330-42CC-A627-CE752D95F99CQ38934306-592072F7-D339-4E41-B0F9-1D5C51F38F43Q40854700-AF053F5F-D005-4137-B815-C4C1EB5973DFQ41016215-D4864712-E66F-4F6F-AAE1-1F4BE86B974EQ41079334-F9DBE581-8B99-456E-BA89-A08FE4613FCBQ41101444-02394948-79C2-4C95-BE15-4D278C68E55EQ41108182-F9BE42F2-36D5-45CC-AC0C-2105A4E8EFDA
P2860
Isoform-specific antagonists of exchange proteins directly activated by cAMP
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@ast
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@en
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@nl
type
label
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@ast
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@en
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@nl
prefLabel
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@ast
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@en
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@nl
P2093
P2860
P356
P1476
Isoform-specific antagonists of exchange proteins directly activated by cAMP
@en
P2093
Colin A Leech
Fang C Mei
George G Holz
Oleg G Chepurny
Tamara Tsalkova
Virgil L Woods
Xiaodong Cheng
P2860
P304
18613-18618
P356
10.1073/PNAS.1210209109
P407
P577
2012-10-22T00:00:00Z