The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome
about
Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3Preclinical evaluation of engineered oncolytic herpes simplex virus for the treatment of pediatric solid tumorsHerpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.UL27.5 is a novel gamma2 gene antisense to the herpes simplex virus 1 gene encoding glycoprotein B.Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virusSerial passage through human glioma xenografts selects for a Deltagamma134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors.Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors.The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript.Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene.A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22.Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase.The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosineTranscription of the derepressed open reading frame P of herpes simplex virus 1 precludes the expression of the antisense gamma(1)34.5 gene and may account for the attenuation of the mutant virusHIV-1(89.6) Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in miceThe product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site.An acutely and latently expressed herpes simplex virus 2 viral microRNA inhibits expression of ICP34.5, a viral neurovirulence factor.Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1.Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells.Open reading frame P--a herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNASpread and replication of and immune response to gamma134.5-negative herpes simplex virus type 1 vectors in BALB/c mice.Functional interaction and colocalization of the herpes simplex virus 1 major regulatory protein ICP4 with EAP, a nucleolar-ribosomal proteinThe N terminus and C terminus of herpes simplex virus 1 ICP4 cooperate to activate viral gene expression.Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cellsMarek's disease virus latency-associated transcripts belong to a family of spliced RNAs that are antisense to the ICP4 homolog gene.Shuttling of the herpes simplex virus type 1 regulatory protein ICP27 between the nucleus and cytoplasm mediates the expression of late proteins.Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA.The γ134.5 Neurovirulence Gene of Herpes Simplex Virus 1 Modifies the Exosome Secretion Profile in Epithelial Cells.
P2860
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P2860
The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
The regulation of synthesis an ...... herpes simplex virus 1 genome
@ast
The regulation of synthesis an ...... herpes simplex virus 1 genome
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type
label
The regulation of synthesis an ...... herpes simplex virus 1 genome
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The regulation of synthesis an ...... herpes simplex virus 1 genome
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prefLabel
The regulation of synthesis an ...... herpes simplex virus 1 genome
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The regulation of synthesis an ...... herpes simplex virus 1 genome
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P2860
P1433
P1476
The regulation of synthesis an ...... herpes simplex virus 1 genome
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P2093
M Lagunoff
P2860
P304
P407
P577
1995-06-01T00:00:00Z