A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides.
about
Parasitic diarrheal disease: drug development and targetsDrug Resistance in the Microaerophilic Parasite Giardia lambliaNewer antibacterial drugs for a new century.Nitazoxanide inhibits biofilm formation by Staphylococcus epidermidis by blocking accumulation on surfaces.Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases).Exploiting the drug-activating properties of a novel trypanosomal nitroreductase.Targeting the substrate preference of a type I nitroreductase to develop antitrypanosomal quinone-based prodrugs.Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lambliaEFFICACY OF NITAZOXANIDE AGAINST Toxocara canis: LARVAL RECOVERY AND HUMORAL IMMUNE RESPONSE IN EXPERIMENTALLY INFECTED MICE.Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds.Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target.Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options.Nitazoxanide: nematicidal mode of action and drug combination studies.Transcriptomics Indicates Active and Passive Metronidazole Resistance Mechanisms in Three Seminal Giardia Lines.Evaluating 5-Nitrothiazoles as Trypanocidal Agents.Understanding drug resistance in human intestinal protozoa.Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis.Effects of (1E,4E)-2-Methyl-1,5-bis(4-nitrophenyl)penta-1,4-dien-3-one on Trypanosoma cruzi and Its Combinational Effect with Benznidazole, Ketoconazole, or Fluconazole.Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication.Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2).A review on metronidazole: an old warhorse in antimicrobial chemotherapy.Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis.Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs.
P2860
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P2860
A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
A novel Giardia lamblia nitror ...... oxanide and other thiazolides.
@ast
A novel Giardia lamblia nitror ...... oxanide and other thiazolides.
@en
type
label
A novel Giardia lamblia nitror ...... oxanide and other thiazolides.
@ast
A novel Giardia lamblia nitror ...... oxanide and other thiazolides.
@en
prefLabel
A novel Giardia lamblia nitror ...... oxanide and other thiazolides.
@ast
A novel Giardia lamblia nitror ...... oxanide and other thiazolides.
@en
P2093
P2860
P356
P1476
A novel Giardia lamblia nitror ...... oxanide and other thiazolides.
@en
P2093
Andrew Hemphill
Joachim Müller
Jonathan Wastling
Norbert Müller
Sanya Sanderson
P2860
P304
P356
10.1128/AAC.01548-06
P407
P577
2007-04-16T00:00:00Z