Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo. - Wikidata - awgldk - TriplyDB

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.

http://www.wikidata.org/entity/Q35842129

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Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitus Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils p21-Activated kinase inhibitors: a patent review Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.Yin-yang and Zheng: Exported from Chinese medicine.Gelidium elegans Regulates the AMPK-PRDM16-UCP-1 Pathway and Has a Synergistic Effect with Orlistat on Obesity-Associated Features in Mice Fed a High-Fat Diet YES, a Src family kinase, is a proximal glucose-specific activator of cell division cycle control protein 42 (Cdc42) in pancreatic islet β cells Systematic Synergy of Glucose and GLP-1 to Stimulate Insulin Secretion Revealed by Quantitative Phosphoproteomics.Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanisms Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.Syntaxin 4 Overexpression Ameliorates Effects of Aging and High-Fat Diet on Glucose Control and Extends Lifespan Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms Dynamin 2 regulates biphasic insulin secretion and plasma glucose homeostasis A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.Putting Rac1 on the path to glucose uptake.Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets.Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry.Pak3 promotes cell cycle exit and differentiation of β-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice.Mouse models of PAK function.p21-Activated protein kinases and their emerging roles in glucose homeostasis.Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation.Rho GTPases in insulin-stimulated glucose uptake.P21 activated kinases: structure, regulation, and functions.Novel approaches to drug discovery for the treatment of type 2 diabetes.Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes.The skeleton in the closet: actin cytoskeletal remodeling in β-cell function.Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.The P21-activated kinase PAK4 is implicated in fatty-acid potentiation of insulin secretion downstream of free fatty acid receptor 1.The incretin hormone GLP-1 and mechanisms underlying its secretion.Hepatic functions of GLP-1 and its based drugs: current disputes and perspectives.A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle.Actin dynamics regulated by the balance of neuronal Wiskott-Aldrich syndrome protein (N-WASP) and cofilin activities determines the biphasic response of glucose-induced insulin secretion.Depletion of PAK1 enhances ubiquitin-mediated survivin degradation in pancreatic β-cells.The response to PAK1 inhibitor IPA3 distinguishes between cancer cells with mutations in BRAF and Ras oncogenes.PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells.

P2860

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P2860

Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.

http://www.wikidata.org/entity/Q35842129

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Inhibition or ablation of p21- ...... omeostatic mechanisms in vivo.

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Inhibition or ablation of p21- ...... omeostatic mechanisms in vivo.

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type

label

Inhibition or ablation of p21- ...... omeostatic mechanisms in vivo.

@ast

Inhibition or ablation of p21- ...... omeostatic mechanisms in vivo.

@en

prefLabel

Inhibition or ablation of p21- ...... omeostatic mechanisms in vivo.

@ast

Inhibition or ablation of p21- ...... omeostatic mechanisms in vivo.

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JBC.M111.291500

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Journal of Biological Chemistry

P1476

Inhibition or ablation of p21- ...... omeostatic mechanisms in vivo.

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P2093

D Wade Clapp

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Debbie C Thurmond

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Eunjin Oh

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Zhanxiang Wang

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P2860

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth

The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells.

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

Ceramide- and oxidant-induced insulin resistance involve loss of insulin-dependent Rac-activation and actin remodeling in muscle cells

Munc18c depletion selectively impairs the sustained phase of insulin release

Insulin activates a p21-activated kinase in muscle cells via phosphatidylinositol 3-kinase

Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells

Pancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcription

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41359-41367

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10.1074/JBC.M111.291500

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48

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286

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Jonathan Chernoff

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3308848

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