Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase. - Wikidata - awgldk - TriplyDB

Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase.

Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase.

http://www.wikidata.org/entity/Q35842836

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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy Targeting epoxides for organ damage in hypertension Red blood cells (RBCs), epoxyeicosatrienoic acids (EETs) and adenosine triphosphate (ATP)Soluble epoxide hydrolase gene deletion attenuates renal injury and inflammation with DOCA-salt hypertension Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation Pharmacological inhibition of soluble epoxide hydrolase ameliorates diet-induced metabolic syndrome in rats Epoxides and soluble epoxide hydrolase in cardiovascular physiology Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats.Inhibition of the soluble epoxide hydrolase promotes albuminuria in mice with progressive renal disease Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.Epoxyeicosatrienoic acid analogue lowers blood pressure through vasodilation and sodium channel inhibition.Epoxyeicosatrienoic acid analog attenuates angiotensin II hypertension and kidney injury.Inhibition of soluble epoxide hydrolase prevents renal interstitial fibrosis and inflammation.Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.Subcutaneous connective tissue reactions to various endodontic biomaterials: an animal study Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats.Pharmacological inhibition of soluble epoxide hydrolase prevents renal interstitial fibrogenesis in obstructive nephropathy.Arrhythmogenic Remodeling in Murine Models of Deoxycorticosterone Acetate-Salt-Induced and 5/6-Subtotal Nephrectomy-Salt-Induced Cardiorenal Disease Altered release of cytochrome p450 metabolites of arachidonic acid in renovascular disease.The red blood cell participates in regulation of the circulation by producing and releasing epoxyeicosatrienoic acids Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats.Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models.Contribution of endothelium-derived hyperpolarizing factors to the regulation of vascular tone in humans.Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells.Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive.Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension.The Soluble Epoxide Hydrolase Inhibitor AR9281 Decreases Blood Pressure, Ameliorates Renal Injury and Improves Vascular Function in Hypertension.The DOCA-Salt Hypertensive Rat as a Model of Cardiovascular Oxidative and Inflammatory Stress Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease.Design and discovery of soluble epoxide hydrolase inhibitors for the treatment of cardiovascular diseases.Activation of peroxisome proliferator-activated receptor-γ downregulates soluble epoxide hydrolase in cardiomyocytes.Peptidyl-urea based inhibitors of soluble epoxide hydrolases.Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart.Chronic inhibition of fatty acid amide hydrolase by URB597 produces differential effects on cardiac performance in normotensive and hypertensive rats.

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P2860

Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase.

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Cell Biochemistry and Biophysics

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Andrew Hoey

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Bruce O Hammock

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Christophe Morisseau

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David Loch

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Lindsay Brown

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P2860

Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats

Experimental and/or genetically controlled alterations of the renal microsomal cytochrome P450 epoxygenase induce hypertension in rats fed a high salt diet

Attenuation of tobacco smoke-induced lung inflammation by treatment with a soluble epoxide hydrolase inhibitor

Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension

Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation

P-450 metabolites of arachidonic acid in the control of cardiovascular function

Influence of enalapril on the endothelial function of DOCA-salt hypertensive rats.

The kidney cytochrome P-450 2C23 arachidonic acid epoxygenase is upregulated during dietary salt loading.

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