Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin
about
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinasesLinker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structureGlobal analysis of the relationship between JIL-1 kinase and transcription.JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in DrosophilaEnrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.Genome-wide identification of chromatin transitional regions reveals diverse mechanisms defining the boundary of facultative heterochromatinA balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila.The epigenetic H3S10 phosphorylation mark is required for counteracting heterochromatic spreading and gene silencing in Drosophila melanogasterReduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase.Protein interactions on telomeric retrotransposons in Drosophila.The COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatinRNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila.Protein phosphatase PP1 is required for normal DNA methylation in Neurospora.The effect of JIL-1 on position-effect variegation is proportional to the total amount of heterochromatin in the genome.Chromatin structure and the inheritance of epigenetic information.H3S10 phosphorylation by the JIL-1 kinase regulates H3K9 dimethylation and gene expression at the white locus in Drosophila.
P2860
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P2860
Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Loss-of-function alleles of th ...... in Drosophila heterochromatin
@ast
Loss-of-function alleles of th ...... in Drosophila heterochromatin
@en
type
label
Loss-of-function alleles of th ...... in Drosophila heterochromatin
@ast
Loss-of-function alleles of th ...... in Drosophila heterochromatin
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prefLabel
Loss-of-function alleles of th ...... in Drosophila heterochromatin
@ast
Loss-of-function alleles of th ...... in Drosophila heterochromatin
@en
P2093
P2860
P1433
P1476
Loss-of-function alleles of th ...... in Drosophila heterochromatin
@en
P2093
Jack Girton
Jørgen Johansen
Kristen M Johansen
P2860
P304
P356
10.1534/GENETICS.107.073676
P407
P50
P577
2007-04-15T00:00:00Z