Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.
about
Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrateEngineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced ActivityInsights into the molecular mechanism of allostery in Hsp70s.DNAJs: more than substrate delivery to HSPAPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functionsThe ensemble nature of allosteryNMR insights into protein allosteryInsights into Hsp70 Chaperone Activity from a Crystal Structure of the Yeast Hsp110 Sse1Structural Basis of J Cochaperone Binding and Regulation of Hsp70Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining ConformationAllosteric Coupling between the Lid and Interdomain Linker in DnaK Revealed by Inhibitor Binding StudiesSolution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrateAllosteric opening of the polypeptide-binding site when an Hsp70 binds ATPStructural basis for the inhibition of HSP70 and DnaK chaperones by small-molecule targeting of a C-terminal allosteric pocketSubstrate-binding domain conformational dynamics mediate Hsp70 allosteryAllostery in the Hsp70 chaperone proteinsClose and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiPIdentification of key hinge residues important for nucleotide-dependent allostery in E. coli Hsp70/DnaKConstructing fluorogenic Bacillus spores (F-spores) via hydrophobic decoration of coat proteinsAllostery in Hsp70 chaperones is transduced by subdomain rotationsThe HSP70 chaperone machinery: J proteins as drivers of functional specificityHeterogeneous binding of the SH3 client protein to the DnaK molecular chaperone.HSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.Inhibitors of difficult protein-protein interactions identified by high-throughput screening of multiprotein complexes.Kinks, loops, and protein folding, with protein A as an example.Pathways of allosteric regulation in Hsp70 chaperones.Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove.Small molecule DnaK modulators targeting the beta-domain.Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40.Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligasesHierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesStructure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.Role of Hsp70 ATPase domain intrinsic dynamics and sequence evolution in enabling its functional interactions with NEFs.Measurement and interpretation of 15N-1H residual dipolar couplings in larger proteins.Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonanceRole of the loop L4,5 in allosteric regulation in mtHsp70s: in vivo significance of domain communication and its implications in protein translocationKinetic and structural characterization of human mortalinThe Hsp40 J-domain stimulates Hsp70 when tethered by the client to the ATPase domain.
P2860
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P2860
Hsp70 chaperone ligands control domain association via an allosteric mechanism mediated by the interdomain linker.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Hsp70 chaperone ligands contro ...... ted by the interdomain linker.
@ast
Hsp70 chaperone ligands contro ...... ted by the interdomain linker.
@en
type
label
Hsp70 chaperone ligands contro ...... ted by the interdomain linker.
@ast
Hsp70 chaperone ligands contro ...... ted by the interdomain linker.
@en
prefLabel
Hsp70 chaperone ligands contro ...... ted by the interdomain linker.
@ast
Hsp70 chaperone ligands contro ...... ted by the interdomain linker.
@en
P2093
P2860
P1433
P1476
Hsp70 chaperone ligands contro ...... ted by the interdomain linker.
@en
P2093
Diana L Montgomery
Gizem Dinler
Joanna F Swain
Lila M Gierasch
Mathias Stotz
Renuka Sivendran
P2860
P356
10.1016/J.MOLCEL.2007.02.020
P577
2007-04-01T00:00:00Z