MYC levels govern hematopoietic tumor type and latency in transgenic mice
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Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYCInduction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model.Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expressionInhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia.Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemiaNotch is oncogenic dominant in T-cell acute lymphoblastic leukemia.Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.Myc roles in hematopoiesis and leukemiaCharacterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms.FoxO3 suppresses Myc-driven lymphomagenesis.The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis.A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL)The future of small molecule inhibitors in lymphoma.Emerging therapies for B-cell non-Hodgkin lymphoma.c-Myc induction of programmed cell death may contribute to carcinogenesis: a perspective inspired by several concepts of chemical carcinogenesis.MYC oncogene in myeloid neoplasias.ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors.c-Myc deregulation induces mRNA capping enzyme dependency.Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression.RUNX1-ETO deregulates the proliferation and growth factor responsiveness of human hematopoietic progenitor cells downstream of the myeloid transcription factor, MYCT1.Mnt modulates Myc-driven lymphomagenesis.How lymphocytes add up.A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses.MYC fails to efficiently shape malignant transformation in T-cell acute lymphoblastic leukemia.Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis.
P2860
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P2860
MYC levels govern hematopoietic tumor type and latency in transgenic mice
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
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2006年论文
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name
MYC levels govern hematopoietic tumor type and latency in transgenic mice
@ast
MYC levels govern hematopoietic tumor type and latency in transgenic mice
@en
type
label
MYC levels govern hematopoietic tumor type and latency in transgenic mice
@ast
MYC levels govern hematopoietic tumor type and latency in transgenic mice
@en
prefLabel
MYC levels govern hematopoietic tumor type and latency in transgenic mice
@ast
MYC levels govern hematopoietic tumor type and latency in transgenic mice
@en
P2093
P2860
P1433
P1476
MYC levels govern hematopoietic tumor type and latency in transgenic mice
@en
P2093
Alan W Harris
Darrin P Smith
Mary L Bath
P2860
P304
P356
10.1182/BLOOD-2006-01-0172
P407
P577
2006-03-14T00:00:00Z