Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.
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Insights into the channel gating of P2X receptors from structures, dynamics and small moleculesExploring the ATP-binding site of P2X receptorsPrinciples and properties of ion flow in P2X receptorsInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsThe use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy.Neuromodulation by extracellular ATP and P2X receptors in the CNS.The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel.Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptorRoles of the lateral fenestration residues of the P2X₄ receptor that contribute to the channel function and the deactivation effect of ivermectinInvolvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channelSubtype-specific control of P2X receptor channel signaling by ATP and Mg2+.Structural and molecular modeling features of P2X receptors.Heteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Metal bridges to probe membrane ion channel structure and function.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.P2X receptorsP2X Receptor Activation.Inter-subunit disulfide locking of the human P2X3 receptor elucidates ectodomain movements associated with channel gatingConformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.Use of chimeras, point mutants, and molecular modeling to map the antagonist-binding site of 4,4',4″,4‴-(carbonylbis-(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakisbenzene-1,3-disulfonic acid (NF449) at P2X1 receptors for ATP.Mass spectrometry analysis of human P2X1 receptors; insight into phosphorylation, modelling and conformational changes.Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies.Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.Structural insights into the competitive inhibition of the ATP-gated P2X receptor channelVoltage- and ATP-dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore.P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation.Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors.The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.Druggable negative allosteric site of P2X3 receptors.Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.
P2860
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P2860
Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.
description
2012 nî lūn-bûn
@nan
2012年の論文
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2012年論文
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2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
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2012年论文
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2012年论文
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name
Agonist binding evokes extensi ...... man P2X1 receptor ion channel.
@ast
Agonist binding evokes extensi ...... man P2X1 receptor ion channel.
@en
type
label
Agonist binding evokes extensi ...... man P2X1 receptor ion channel.
@ast
Agonist binding evokes extensi ...... man P2X1 receptor ion channel.
@en
prefLabel
Agonist binding evokes extensi ...... man P2X1 receptor ion channel.
@ast
Agonist binding evokes extensi ...... man P2X1 receptor ion channel.
@en
P2093
P2860
P356
P1476
Agonist binding evokes extensi ...... uman P2X1 receptor ion channel
@en
P2093
Catherine Vial
Jonathan A Roberts
Rebecca C Allsopp
Richard J Evans
Sam El Ajouz
P2860
P304
P356
10.1073/PNAS.1201872109
P407
P577
2012-03-05T00:00:00Z