Agonist trapped in ATP-binding sites of the P2X2 receptor.
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesTwo open states of P2X receptor channelsExploring the ATP-binding site of P2X receptorsSize matters in activation/inhibition of ligand-gated ion channelsCharacterization of ATPase Activity of P2RX2 Cation ChannelInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsMolecular mechanism of ATP binding and ion channel activation in P2X receptorsTightening of the ATP-binding sites induces the opening of P2X receptor channelsRegulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsExpression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA.Identification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.Inherent dynamics of head domain correlates with ATP-recognition of P2X4 receptors: insights gained from molecular simulations.Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsAgonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel.Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.Allosteric nature of P2X receptor activation probed by photoaffinity labelling.Photo-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channelA Highly Conserved Salt Bridge Stabilizes the Kinked Conformation of β2,3-Sheet Essential for Channel Function of P2X4 ReceptorsInter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.Optical control of trimeric P2X receptors and acid-sensing ion channelsStructural and molecular modeling features of P2X receptors.Novel approaches to drug design for the treatment of schizophrenia.Heteromeric assembly of P2X subunits.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gatingP2X receptorsP2X Receptor Activation.Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening.Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.P2X receptor intermediate activation states have altered nucleotide selectivity.The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.
P2860
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P2860
Agonist trapped in ATP-binding sites of the P2X2 receptor.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Agonist trapped in ATP-binding sites of the P2X2 receptor.
@ast
Agonist trapped in ATP-binding sites of the P2X2 receptor.
@en
type
label
Agonist trapped in ATP-binding sites of the P2X2 receptor.
@ast
Agonist trapped in ATP-binding sites of the P2X2 receptor.
@en
prefLabel
Agonist trapped in ATP-binding sites of the P2X2 receptor.
@ast
Agonist trapped in ATP-binding sites of the P2X2 receptor.
@en
P2093
P2860
P356
P1476
Agonist trapped in ATP-binding sites of the P2X2 receptor
@en
P2093
Adeline Martz
Damien Lemoine
Lia Prado de Carvalho
Ruotian Jiang
Sophie Gonin
Thomas Grutter
P2860
P304
P356
10.1073/PNAS.1102170108
P407
P577
2011-05-16T00:00:00Z