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Human aneuploidy: mechanisms and new insights into an age-old problemDeconstructing Mus gemischus: advances in understanding ancestry, structure, and variation in the genome of the laboratory mousePremature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytesBivalent separation into univalents precedes age-related meiosis I errors in oocytes.Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1How separated sisters get bad connections.Arrested human embryos are more likely to have abnormal chromosomes than developing embryos from women of advanced maternal age.Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice.Rejuvenation of meiotic cohesion in oocytes during prophase I is required for chiasma maintenance and accurate chromosome segregation.Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes.Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.Identification of chromosomal errors in human preimplantation embryos with oligonucleotide DNA microarray.The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.Assessment of aneuploidy formation in human blastocysts resulting from cryopreserved donor eggs.Revisiting germinal vesicle transfer as a treatment for aneuploidy in infertile women with diminished ovarian reserveMaternal Germinal Trisomy 21 in Down SyndromeIncreased exposure to acute thermal stress is associated with a non-linear increase in recombination frequency and an independent linear decrease in fitness in Drosophila.Assessment of aneuploidy formation in human blastocysts resulting from donated eggs and the necessity of the embryos for aneuploidy screening.The roles of cohesins in mitosis, meiosis, and human health and disease.Age-related aneuploidy through cohesion exhaustion.Transmission of trisomy decreases with maternal age in mouse models of Down syndrome, mirroring a phenomenon in human Down syndrome mothersMulticohort analysis of the maternal age effect on recombinationDNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age.Chromosome cohesion decreases in human eggs with advanced maternal age.Aneuploidy.The role of mitochondria from mature oocyte to viable blastocyst.Association of maternal mRNA and phosphorylated EIF4EBP1 variants with the spindle in mouse oocytes: localized translational control supporting female meiosis in mammals.Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differencesMolecular cytogenetic analysis of early spontaneous abortions conceived from varying assisted reproductive technology procedures.Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors.The prevalence of chromosomal deletions relating to developmental delay and/or intellectual disability in human euploid blastocysts.The association between the oocyte pool and aneuploidy: a comparative study of the reproductive potential of young and aged mice.Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of changes in transcript levels with oocyte protein expression.Early human embryos are naturally aneuploid-can that be corrected?Reprogenetics: Preimplantational genetics diagnosis.Effects of embryonic manipulation and epigenetics.Sperm guidance to the egg finds calcium at the helm.The adverse outcome pathway (AOP) for chemical binding to tubulin in oocytes leading to aneuploid offspring.The lipid peroxidation product 4-hydroxynonenal contributes to oxidative stress-mediated deterioration of the ageing oocyte.
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Meiotic origins of maternal age-related aneuploidy.
@ast
Meiotic origins of maternal age-related aneuploidy.
@en
type
label
Meiotic origins of maternal age-related aneuploidy.
@ast
Meiotic origins of maternal age-related aneuploidy.
@en
prefLabel
Meiotic origins of maternal age-related aneuploidy.
@ast
Meiotic origins of maternal age-related aneuploidy.
@en
P2093
P2860
P1476
Meiotic origins of maternal age-related aneuploidy.
@en
P2093
Michael A Lampson
Richard M Schultz
Teresa Chiang
P2860
P356
10.1095/BIOLREPROD.111.094367
P407
P577
2012-01-10T00:00:00Z