Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
about
SuperBiHelix method for predicting the pleiotropic ensemble of G-protein-coupled receptor conformations.Ligand- and mutation-induced conformational selection in the CCR5 chemokine G protein-coupled receptorBihelix: Towards de novo structure prediction of an ensemble of G-protein coupled receptor conformations.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Experimental validation of the predicted binding site of Escherichia coli K1 outer membrane protein A to human brain microvascular endothelial cells: identification of critical mutations that prevent E. coli meningitis.Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptorElucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches.Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cellsPredicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptorMolecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 ReceptorStructure and dynamics of a constitutively active neurotensin receptor.Structure-based prediction of subtype selectivity of histamine H3 receptor selective antagonists in clinical trialsThe predicted ensemble of low-energy conformations of human somatostatin receptor subtype 5 and the binding of antagonists.Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor.Predicted structures and dynamics for agonists and antagonists bound to serotonin 5-HT2B and 5-HT2C receptors.Prediction of the three-dimensional structure for the rat urotensin II receptor, and comparison of the antagonist binding sites and binding selectivity between human and rat receptors from atomistic simulations.Predicted 3D structures of olfactory receptors with details of odorant binding to OR1G1.Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.Predicted ligands for the human urotensin-II G protein-coupled receptor with some experimental validation.
P2860
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P2860
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
@ast
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
@en
type
label
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
@ast
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
@en
prefLabel
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
@ast
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
@en
P2860
P356
P1476
Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements.
@en
P2093
Victor Wai Tak Kam
William A Goddard
P2860
P304
P356
10.1021/CT800196K
P577
2008-12-01T00:00:00Z