Characterization of physical and functional anchor site interactions in human telomerase.
about
It all comes together at the ends: telomerase structure, function, and biogenesisInhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13pHuman telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivoMutation in TERT separates processivity from anchor-site function.The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomeraseThe N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalizationA novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity.A mutation in the catalytic subunit of yeast telomerase alters primer-template alignment while promoting processivity and protein-DNA binding.Coordinated DNA dynamics during the human telomerase catalytic cycle.A self-regulating template in human telomerase.Ribonucleoprotein multimers and their functions.InTERTpreting telomerase structure and functionThe non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomeraseDirect involvement of the TEN domain at the active site of human telomeraseTelomere repeat binding proteins are functional components of Arabidopsis telomeres and interact with telomerase.Human telomerase model shows the role of the TEN domain in advancing the double helix for the next polymerization step.Molecular adaptation of telomere associated genes in mammals.RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency.The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids.A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization.Structure-function relationships in telomerase genes.Medical genetics and epigenetics of telomerase.Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme.TERRA mimicking ssRNAs prevail over the DNA substrate for telomerase in vitro due to interactions with the alternative binding site.Multiple DNA-binding sites in Tetrahymena telomerase.An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.hTERT mutations associated with idiopathic pulmonary fibrosis affect telomerase activity, telomere length, and cell growth by distinct mechanisms.Human telomerase specialization for repeat synthesis by unique handling of primer-template duplex.A web of interactions at the ends.Striking similarities in diverse telomerase proteins revealed by combining structure prediction and machine learning approaches.Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding.Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.Direct observation of nucleic acid binding dynamics by the telomerase essential N-terminal domain.
P2860
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P2860
Characterization of physical and functional anchor site interactions in human telomerase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Characterization of physical and functional anchor site interactions in human telomerase.
@ast
Characterization of physical and functional anchor site interactions in human telomerase.
@en
type
label
Characterization of physical and functional anchor site interactions in human telomerase.
@ast
Characterization of physical and functional anchor site interactions in human telomerase.
@en
prefLabel
Characterization of physical and functional anchor site interactions in human telomerase.
@ast
Characterization of physical and functional anchor site interactions in human telomerase.
@en
P2093
P2860
P356
P1476
Characterization of physical and functional anchor site interactions in human telomerase.
@en
P2093
Deirdre A Lobb
Haley D M Wyatt
Tara L Beattie
P2860
P304
P356
10.1128/MCB.02368-06
P407
P577
2007-02-12T00:00:00Z