CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
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Functional organization of human SAMHD1 and mechanisms of HIV-1 restrictionMicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients.Subversion of Cell Cycle Regulatory Mechanisms by HIV.Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cellsImpaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592Phosphorylation of murine SAMHD1 regulates its antiretroviral activityInhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.HIV-1 and HIV-2 exhibit divergent interactions with HLTF and UNG2 DNA repair proteinsEffects of T592 phosphomimetic mutations on tetramer stability and dNTPase activity of SAMHD1 can not explain the retroviral restriction defect.A G1-like state allows HIV-1 to bypass SAMHD1 restriction in macrophages.The druggability of intracellular nucleotide-degrading enzymes.A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability.SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.Role of Innate Genes in HIV Replication.CD81 association with SAMHD1 enhances HIV-1 reverse transcription by increasing dNTP levels.The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase.Substrate Specificity of SAMHD1 Triphosphohydrolase Activity Is Controlled by Deoxyribonucleoside Triphosphates and Phosphorylation at Thr592.The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response.Interferons: Reprogramming the Metabolic Network against Viral Infection.A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation.Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.The role of SAMHD1 expression and its relation to HIV-2 (Vpx) gene productionThe dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1
P2860
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P2860
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
description
2015 nî lūn-bûn
@nan
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
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2015年论文
@zh-cn
name
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
@ast
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
@en
type
label
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
@ast
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
@en
prefLabel
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
@ast
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
@en
P2093
P2860
P356
P1476
CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.
@en
P2093
Jacek Skowronski
Jinwoo Ahn
Junpeng Yan
Maria DeLucia
Selene Swanson
P2860
P304
13279-13292
P356
10.1074/JBC.M115.646588
P407
P577
2015-04-06T00:00:00Z