Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease.
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Specificity of interaction of INI1/hSNF5 with retroviral integrases and its functional significanceContribution of the C-terminal tri-lysine regions of human immunodeficiency virus type 1 integrase for efficient reverse transcription and viral DNA nuclear importA novel function for spumaretrovirus integrase: an early requirement for integrase-mediated cleavage of 2 LTR circles.Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in MaturationAllosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturationRequirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase.A single amino acid substitution in HIV-1 reverse transcriptase significantly reduces virion release.Human immunodeficiency virus type 1 integrase protein promotes reverse transcription through specific interactions with the nucleoprotein reverse transcription complex.The foamy virus genome remains unintegrated in the nuclei of G1/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus.Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.Mutations of the human immunodeficiency virus type 1 p6Gag domain result in reduced retention of Pol proteins during virus assembly.Integrase-lexA fusion proteins incorporated into human immunodeficiency virus type 1 that contains a catalytically inactive integrase gene are functional to mediate integrationTargeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.Role of human immunodeficiency virus type 1 integrase in uncoating of the viral core.Moloney murine leukemia virus integrase protein augments viral DNA synthesis in infected cells.Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking.Virion instability of human immunodeficiency virus type 1 reverse transcriptase (RT) mutated in the protease cleavage site between RT p51 and the RT RNase H domain.Altered viral fitness and drug susceptibility in HIV-1 carrying mutations that confer resistance to nonnucleoside reverse transcriptase and integrase strand transfer inhibitors.Redundant roles for nucleocapsid and matrix RNA-binding sequences in human immunodeficiency virus type 1 assembly.Placement of leucine zipper motifs at the carboxyl terminus of HIV-1 protease significantly reduces virion production.A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import.The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.Elimination of protease activity restores efficient virion production to a human immunodeficiency virus type 1 nucleocapsid deletion mutant.Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.HIV-1 replication in cell lines harboring INI1/hSNF5 mutations.Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag.The allosteric HIV-1 integrase inhibitor BI-D affects virion maturation but does not influence packaging of a functional RNA genomeNef association with human immunodeficiency virus type 1 virions and cleavage by the viral proteaseStructure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.Incorporation of Pr160(gag-pol) into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein.Incorporation of functional human immunodeficiency virus type 1 integrase into virions independent of the Gag-Pol precursor protein.von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.HIV DNA integration.Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription.Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication.Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis.INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivoIdentifying and characterizing a functional HIV-1 reverse transcriptase-binding site on integrase.Integrase interacts with nucleoporin NUP153 to mediate the nuclear import of human immunodeficiency virus type 1
P2860
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P2860
Lack of integrase can markedly affect human immunodeficiency virus type 1 particle production in the presence of an active viral protease.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
1996年论文
@zh
1996年论文
@zh-cn
name
Lack of integrase can markedly ...... e of an active viral protease.
@ast
Lack of integrase can markedly ...... e of an active viral protease.
@en
type
label
Lack of integrase can markedly ...... e of an active viral protease.
@ast
Lack of integrase can markedly ...... e of an active viral protease.
@en
prefLabel
Lack of integrase can markedly ...... e of an active viral protease.
@ast
Lack of integrase can markedly ...... e of an active viral protease.
@en
P2860
P1433
P1476
Lack of integrase can markedly ...... e of an active viral protease.
@en
P2093
A Bukovsky
H Göttlinger
P2860
P304
P407
P577
1996-10-01T00:00:00Z