The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist
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125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptorThe 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonistStructure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and CaffeineHydrophilic side chains in the third and seventh transmembrane helical domains of human A2A adenosine receptors are required for ligand recognitionThe birth and postnatal development of purinergic signallingHighlights on the development of A(2A) adenosine receptor agonists and antagonistsUse of the triazolotriazine [3H]ZM 241385 as a radioligand at recombinant human A2B adenosine receptors.Potentiation of cytokine induction of group IIA phospholipase A(2) in rat mesangial cells by ATP and adenosine via the A2A adenosine receptorCyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists.Adenosine-mediated hypotension in in vivo guinea-pig: receptors involved and role of NOAdenosine A(2A) receptor enhances GABA(A)-mediated IPSCs in the rat globus pallidusStatic magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeabilityAdenosine stimulates depolarization and rise in cytoplasmic [Ca2+] in type I cells of rat carotid bodiesContribution of adenosine A2A and A2B receptors and heme oxygenase to AMPA-induced dilation of pial arterioles in ratsActivation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils.Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.Enhanced actions of adenosine in medial entorhinal cortex layer II stellate neurons in temporal lobe epilepsy are mediated via A(1)-receptor activation.Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction.Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritisAdenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury.Mechanism of adenosine-induced vasodilation in rat diaphragm microcirculation.Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheep.Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes.Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia.Search for new antagonist ligands for adenosine receptors from QSAR point of view. How close are we?Characterization of the A2B adenosine receptor from mouse, rabbit, and dog.Structure-based discovery of A2A adenosine receptor ligands.Adenosine and ischemic preconditioning.Activation of Trk neurotrophin receptors in the absence of neurotrophinsSubstructure-based virtual screening for adenosine A2A receptor ligands.3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects.Progress in the pursuit of therapeutic adenosine receptor antagonists.Purinergic mechanisms in gliovascular couplingSynthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition processCharacterization of adenosine receptors evoking excitation of mesenteric afferents in the rat.A comparison of an A1 adenosine receptor agonist (CVT-510) with diltiazem for slowing of AV nodal conduction in guinea-pig.A2B adenosine receptors mediate relaxation of the pig intravesical ureter: adenosine modulation of non adrenergic non cholinergic excitatory neurotransmission.Effect of A2A adenosine receptor stimulation and antagonism on synaptic depression induced by in vitro ischaemia in rat hippocampal slices
P2860
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P2860
The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonist
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
The in vitro pharmacology of Z ...... adenosine receptor antagonist
@ast
The in vitro pharmacology of Z ...... adenosine receptor antagonist
@en
type
label
The in vitro pharmacology of Z ...... adenosine receptor antagonist
@ast
The in vitro pharmacology of Z ...... adenosine receptor antagonist
@en
prefLabel
The in vitro pharmacology of Z ...... adenosine receptor antagonist
@ast
The in vitro pharmacology of Z ...... adenosine receptor antagonist
@en
P2093
P2860
P1476
The in vitro pharmacology of Z ...... adenosine receptor antagonist
@en
P2093
Caulkett PW
Poucher SM
Stoggall SM
P2860
P304
P356
10.1111/J.1476-5381.1995.TB15923.X
P407
P577
1995-07-01T00:00:00Z