8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo.
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125I-4-(2-[7-amino-2-[2-furyl][1,2,4]triazolo[2,3-a][1,3,5] triazin-5-yl-amino]ethyl)phenol, a high affinity antagonist radioligand selective for the A2a adenosine receptorCaffeine activates mouse TRPA1 channels but suppresses human TRPA1 channelsThe stimulant effects of caffeine on locomotor behaviour in mice are mediated through its blockade of adenosine A(2A) receptorsAdenosine receptor antagonists induce persistent bursting in the rat hippocampal CA3 region via an NMDA receptor-dependent mechanismEffects of an adenosine A2A receptor blockade in the nucleus accumbens on locomotion, feeding, and prepulse inhibition in ratsStructure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors.Inhibition by adenosine A(2A) receptors of NMDA but not AMPA currents in rat neostriatal neurons.Activation of the A2A adenosine receptor inhibits nitric oxide production in glial cells.Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine.Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration.Nomenclature and classification of purinoceptors.Adenosine A1, but not A2, receptor blockade increases anxiety and arousal in Zebrafish.A role for central A3-adenosine receptors. Mediation of behavioral depressant effectsAdenosine regulation of alveolar fluid clearanceThe impact of commercially available purinergic ligands on purinergic signalling research.The in vitro pharmacology of ZM 241385, a potent, non-xanthine A2a selective adenosine receptor antagonistPharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 bindingDysregulation of brain adenosine is detrimental to the expression of conditioned freezing but not general Pavlovian learningCerebral ischemia in gerbils: effects of acute and chronic treatment with adenosine A2A receptor agonist and antagonist.Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes.Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.Direct preconditioning of cultured chick ventricular myocytes. Novel functions of cardiac adenosine A2a and A3 receptors.Lidocaine relaxation in isolated rat aortic rings is enhanced by endothelial removal: possible role of Kv, KATP channels and A2a receptor crosstalk.Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells.Purinoceptors: from history to recent progress. A review.Adenosine stimulates cone photoreceptor myoid elongation via an adenosine A2-like receptor.Effects of pH on responses to adenosine, CGS 21680, carbachol and nitroprusside in the isolated perfused superior mesenteric arterial bed of the rat.The role of adenosine receptors in the central action of caffeineAdenosine A(2A) Receptor Binding Profile of Two Antagonists, ST1535 and KW6002: Consideration on the Presence of Atypical Adenosine A(2A) Binding Sites.Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injuryAntihyperalgesic activity of nucleoside transport inhibitors in models of inflammatory pain in guinea pigsEnhanced neuronal damage by co-administration of quinolinic acid and free radicals, and protection by adenosine A2A receptor antagonists.Effects of the new A2 adenosine receptor antagonist 8FB-PTP, an 8 substituted pyrazolo-triazolo-pyrimidine, on in vitro functional modelsAdenosine A2 receptor-induced inhibition of leukotriene B4 synthesis in whole blood ex vivo.Regulation of photoreceptor gap junction phosphorylation by adenosine in zebrafish retina.Suppression of leukotriene B4 biosynthesis by endogenous adenosine in ligand-activated human neutrophils.8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism.Analysis of adenosine vascular effect in isolated rat aorta: possible role of Na+/K+-ATPase.Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats.Ethanol operant self-administration in rats is regulated by adenosine A2 receptors.
P2860
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P2860
8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
8-(3-Chlorostyryl)caffeine (CS ...... tagonist in vitro and in vivo.
@ast
8-(3-Chlorostyryl)caffeine (CS ...... tagonist in vitro and in vivo.
@en
type
label
8-(3-Chlorostyryl)caffeine (CS ...... tagonist in vitro and in vivo.
@ast
8-(3-Chlorostyryl)caffeine (CS ...... tagonist in vitro and in vivo.
@en
prefLabel
8-(3-Chlorostyryl)caffeine (CS ...... tagonist in vitro and in vivo.
@ast
8-(3-Chlorostyryl)caffeine (CS ...... tagonist in vitro and in vivo.
@en
P2093
P2860
P1433
P1476
8-(3-Chlorostyryl)caffeine (CS ...... tagonist in vitro and in vivo.
@en
P2093
C Gallo-Rodriguez
K A Jacobson
M Maillard
O Nikodijević
W L Padgett
P2860
P304
P356
10.1016/0014-5793(93)81466-D
P407
P577
1993-05-01T00:00:00Z