Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells
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Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensationPIKE-A is amplified in human cancers and prevents apoptosis by up-regulating AktTubulin-interactive natural products as anticancer agentsThe Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical ApplicationsMicrotubule-stabilizing agents as potential therapeutics for neurodegenerative diseasePI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosisPotent anti-inflammatory activity of novel microtubule-modulating brominated noscapine analogsNoscapine induced apoptosis via downregulation of survivin in human neuroblastoma cells having wild type or null p53Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agentsRNA antisense abrogation of MAT1 induces G1 phase arrest and triggers apoptosis in aortic smooth muscle cellsA new antiproliferative noscapine analogue: chemical synthesis and biological evaluationSrc homology domains in phospholipase C-gamma1 mediate its anti-apoptotic action through regulating the enzymatic activity.A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering.Mass spectral studies on aryl-substituted N-carbamoyl/N-thiocarbamoyl narcotine and related compounds.Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction.Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathwayOvary cells apoptosis in opium-addicted diabetic and non-diabetic rats.Antitumor activity of Noscapine in combination with Doxorubicin in triple negative breast cancer.Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced ratsA novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells.Potential of plant-derived natural products in the treatment of leukemia and lymphomaEnhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer.Novel 9'-substituted-noscapines: synthesis with Suzuki cross-coupling, structure elucidation and biological evaluationCharacterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy.A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.Isobenzofuranone derivatives exhibit antileishmanial effect by inhibiting type II DNA topoisomerase and inducing host response.Anticancer activity of Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer.Non-addictive opium alkaloids selectively induce apoptosis in cancer cells compared to normal cells.Drugs that target dynamic microtubules: a new molecular perspectiveSynergistic antimicrotubule therapy for prostate cancerNovel third-generation water-soluble noscapine analogs as superior microtubule-interfering agents with enhanced antiproliferative activity.Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluationA novel effect of Noscapine on patients with massive ischemic stroke: A pseudo-randomized clinical trialCYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism.Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agentsChronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female RatsDrug-resistant T-lymphoid tumors undergo apoptosis selectively in response to an antimicrotubule agent, EM011.Formulation, Pharmacokinetic, and Efficacy Studies of Mannosylated Self-Emulsifying Solid Dispersions of Noscapine.Noscapine recirculates enterohepatically and induces self-clearance.
P2860
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P2860
Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Opium alkaloid noscapine is an ...... es apoptosis in dividing cells
@ast
Opium alkaloid noscapine is an ...... es apoptosis in dividing cells
@en
type
label
Opium alkaloid noscapine is an ...... es apoptosis in dividing cells
@ast
Opium alkaloid noscapine is an ...... es apoptosis in dividing cells
@en
prefLabel
Opium alkaloid noscapine is an ...... es apoptosis in dividing cells
@ast
Opium alkaloid noscapine is an ...... es apoptosis in dividing cells
@en
P2093
P2860
P356
P1476
Opium alkaloid noscapine is an ...... es apoptosis in dividing cells
@en
P2093
P2860
P304
P356
10.1073/PNAS.95.4.1601
P407
P577
1998-02-01T00:00:00Z