Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
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New insights into TB physiology suggest untapped therapeutic opportunitiesFatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infectionBiochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamideMechanisms of Pyrazinamide Action and ResistanceMutually exclusive genotypes for pyrazinamide and 5-chloropyrazinamide resistance reveal a potential resistance-proofing strategy.Pyrazinamide, but not pyrazinoic acid, is a competitive inhibitor of NADPH binding to Mycobacterium tuberculosis fatty acid synthase IMicrobial metabolism of pyrazines.Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.Hybrid antibiotics - clinical progress and novel designs.Synthesis and Antimicrobial Evaluation of 6-Alkylamino-N-phenylpyrazine-2-carboxamides.Synthesis, antimycobacterial activity and in vitro cytotoxicity of 5-chloro-N-phenylpyrazine-2-carboxamides.The antituberculosis drug pyrazinamide affects the course of cutaneous leishmaniasis in vivo and increases activation of macrophages and dendritic cells.Pantothenate and pantetheine antagonize the antitubercular activity of pyrazinamideN-substituted 5-amino-6-methylpyrazine-2,3-dicarbonitriles: microwave-assisted synthesis and biological properties.The Forty-Sixth Euro Congress on Drug Synthesis and Analysis: Snapshot †.New potentially active pyrazinamide derivatives synthesized under microwave conditions.Analogs of the antituberculous agent pyrazinamide are competitive inhibitors of NADPH binding to M. tuberculosis fatty acid synthase I.Design, Synthesis and Evaluation of -pyrazinylbenzamides as Potential Antimycobacterial AgentsExpression of a recombinant, 4'-Phosphopantetheinylated, active M. tuberculosis fatty acid synthase I in E. coliDesign, synthesis and antimycobacterial activity of hybrid molecules combining pyrazinamide with a 4-phenylthiazol-2-amine scaffoldSubstituted N-Benzylpyrazine-2-carboxamides: Synthesis and Biological Evaluation
P2860
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P2860
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Inhibition of isolated Mycobac ...... ase I by pyrazinamide analogs.
@ast
Inhibition of isolated Mycobac ...... ase I by pyrazinamide analogs.
@en
type
label
Inhibition of isolated Mycobac ...... ase I by pyrazinamide analogs.
@ast
Inhibition of isolated Mycobac ...... ase I by pyrazinamide analogs.
@en
prefLabel
Inhibition of isolated Mycobac ...... ase I by pyrazinamide analogs.
@ast
Inhibition of isolated Mycobac ...... ase I by pyrazinamide analogs.
@en
P2093
P2860
P356
P1476
Inhibition of isolated Mycobac ...... hase I by pyrazinamide analogs
@en
P2093
Halimah Sayahi
John T Welch
Oren Zimhony
Silvana C Ngo
Woo Jin Chung
P2860
P304
P356
10.1128/AAC.01458-06
P407
P50
P577
2007-05-07T00:00:00Z